European Radiology

, Volume 23, Issue 3, pp 664–672

Performance comparison of single-view digital breast tomosynthesis plus single-view digital mammography with two-view digital mammography

  • Gisella Gennaro
  • R. Edward Hendrick
  • Patricia Ruppel
  • Roberta Chersevani
  • Cosimo di Maggio
  • Manuela La Grassa
  • Luigi Pescarini
  • Ilaria Polico
  • Alessandro Proietti
  • Enrica Baldan
  • Elisabetta Bezzon
  • Fabio Pomerri
  • Pier Carlo Muzzio
Breast

DOI: 10.1007/s00330-012-2649-1

Cite this article as:
Gennaro, G., Hendrick, R.E., Ruppel, P. et al. Eur Radiol (2013) 23: 664. doi:10.1007/s00330-012-2649-1

Abstract

Objective

To determine the performance of combined single-view mediolateral oblique (MLO) digital breast tomosynthesis (DBT) plus single-view cranio-caudal (CC) mammography (MX) compared with that of standard two-view digital mammography.

Methods

A multi-reader multi-case (MRMC) receiver-operating characteristic (ROC) study was conducted, involving six breast radiologists. Two hundred fifty patients underwent bilateral MX and DBT imaging. MX and DBT images with the adjunct of the CC-MX view from 469 breasts were evaluated and rated independently by six readers. Differences in mean areas under the ROC curves (AUCs), mean sensitivity and mean specificity were analysed by analysis of variance (ANOVA) to assess clinical performance.

Results

The combined technique was found to be non-inferior to standard two-view mammography (MX(CC+MLO)) in mean AUC (difference: +0.021;95 % LCL = −0.011), but was not statistically significant for superiority (P = 0.197). The combined technique had equivalent sensitivity to standard mammography (76.2 % vs. 72.8 %, P = 0.269) and equivalent specificity (84.9 % vs. 83.0 %, P = 0.130). Specificity for benign lesions was significantly higher with the combination of techniques versus mammography (45.6 % vs. 36.8 %, P = 0.002).

Conclusion

In this enriched study population, the combination of single-view MLO tomosynthesis plus single-view CC mammography was non-inferior to that of standard two-view digital mammography in terms of ROC curve area, sensitivity and specificity.

Key Points

• Breast tomosynthesis (DBT) has emerged as a valuable adjunct to mammography (MX).

• Combination DBT/MX demonstrated non-inferior clinical performance to standard two-view MX.

• Combination DBT/MX was superior to two-view MX in recognising benign lesions.

• Combination DBT/MX reduced variability compared with two-view MX.

Keywords

Breast tomosynthesisMammographyTomographyClinical performanceReceiver-operating characteristics

Copyright information

© European Society of Radiology 2012

Authors and Affiliations

  • Gisella Gennaro
    • 1
  • R. Edward Hendrick
    • 2
  • Patricia Ruppel
    • 3
  • Roberta Chersevani
    • 4
  • Cosimo di Maggio
    • 5
  • Manuela La Grassa
    • 6
  • Luigi Pescarini
    • 1
  • Ilaria Polico
    • 1
  • Alessandro Proietti
    • 1
  • Enrica Baldan
    • 1
  • Elisabetta Bezzon
    • 1
  • Fabio Pomerri
    • 1
  • Pier Carlo Muzzio
    • 1
  1. 1.Veneto Institute of Oncology (IOV)–IRCCSPaduaItaly
  2. 2.Department of RadiologyUniversity of Colorado-Denver, School of MedicineAuroraUSA
  3. 3.Innovative AnalyticsKalamazooUSA
  4. 4.Private Clinical PracticeGoriziaItaly
  5. 5.Private Clinical PracticePaduaItaly
  6. 6.Oncological Reference Center (CRO)–IRCCS(Pordenone)Italy