European Radiology

, Volume 23, Issue 1, pp 3–11

Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion recovery, FLAIR and T2W MR imaging

  • Emiko Morimoto
  • Mitsunori Kanagaki
  • Tomohisa Okada
  • Akira Yamamoto
  • Nobuyuki Mori
  • Riki Matsumoto
  • Akio Ikeda
  • Nobuhiro Mikuni
  • Takeharu Kunieda
  • Dominik Paul
  • Susumu Miyamoto
  • Ryosuke Takahashi
  • Kaori Togashi
Neuro

DOI: 10.1007/s00330-012-2565-4

Cite this article as:
Morimoto, E., Kanagaki, M., Okada, T. et al. Eur Radiol (2013) 23: 3. doi:10.1007/s00330-012-2565-4

Abstract

Objectives

To investigate the diagnostic capability of anterior temporal lobe white matter abnormal signal (ATLAS) for determining seizure focus laterality in temporal lobe epilepsy (TLE) by comparing different MR sequences.

Methods

This prospective study was approved by the institutional review board and written informed consent was obtained. Three 3D sequences (double inversion recovery (DIR), fluid-attenuated inversion recovery (FLAIR) and T2-weighted imaging (T2WI)) and two 2D sequences (FLAIR and T2WI) were acquired at 3 T. Signal changes in the anterior temporal white matter of 21 normal volunteers were evaluated. ATLAS laterality was evaluated in 21 TLE patients. Agreement of independent evaluations by two neuroradiologists was assessed using κ statistics. Differences in concordance between ATLAS laterality and clinically defined seizure focus laterality were analysed using McNemar’s test with multiple comparisons.

Results

Pre-amygdala high signals (PAHS) were detected in all volunteers only on 3D-DIR. Inter-evaluator agreement was moderate to almost perfect for each sequence. Correct diagnosis of seizure laterality was significantly more frequent on 3D-DIR than on any other sequences (P ≤ 0.031 for each evaluator).

Conclusions

The most sensitive sequence for detecting ATLAS laterality was 3D-DIR. ATLAS laterality on 3D-DIR can be a good indicator for determining seizure focus localization in TLE.

Key Points

Magnetic resonance imaging is widely used to investigate temporal lobe epilepsy.

Numerous MR sequences can show anterior temporal lobe white matter abnormal signal.

ATLAS on 3D-DIR can frequently indicate seizure focus laterality in TLE.

3D-DIR is more sensitive about ATLAS laterality than T2WI or FLAIR.

Keywords

EpilepsyMagnetic resonance imagingBrainTemporal lobeSequence inversion

Abbreviations and acronyms

ATLAS

anterior temporal lobe white matter abnormal signal

CSF

cerebrospinal fluid

DIR

double inversion recovery

EEG

electroencephalography

FLAIR

fluid-attenuated inversion recovery

MR

magnetic resonance

PAHS

pre-amygdala high signals

TLE

temporal lobe epilepsy

T2WI

T2-weighted imaging

2D

two-dimensional

3D

three-dimensional

Copyright information

© European Society of Radiology 2012

Authors and Affiliations

  • Emiko Morimoto
    • 1
  • Mitsunori Kanagaki
    • 1
  • Tomohisa Okada
    • 1
  • Akira Yamamoto
    • 1
  • Nobuyuki Mori
    • 4
  • Riki Matsumoto
    • 2
  • Akio Ikeda
    • 2
  • Nobuhiro Mikuni
    • 5
  • Takeharu Kunieda
    • 3
  • Dominik Paul
    • 6
  • Susumu Miyamoto
    • 3
  • Ryosuke Takahashi
    • 2
  • Kaori Togashi
    • 1
  1. 1.Department of Diagnostic Imaging and Nuclear MedicineKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Department of NeurologyKyoto University Graduate School of MedicineKyotoJapan
  3. 3.Department of NeurosurgeryKyoto University Graduate School of MedicineKyotoJapan
  4. 4.Department of RadiologyTenri HospitalTenriJapan
  5. 5.Department of NeurosurgerySapporo Medical UniversitySapporoJapan
  6. 6.Siemens AG Healthcare SectorErlangenGermany