Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload
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To evaluate MRI using T1 and T2* mapping sequences in patients with suspected hepatic iron overload (HIO).
Twenty-five consecutive patients with clinically suspected HIO were retrospectively studied. All underwent MRI and liver biopsy. For the quantification of liver T2* values we used a fat-saturated multi-echo gradient echo sequence with 12 echoes (TR = 200 ms, TE = 0.99 ms + n × 1.41 ms, flip angle 20°). T1 values were obtained using a fast T1 mapping sequence based on an inversion recovery snapshot FLASH sequence. Parameter maps were analysed using regions of interest.
ROC analysis calculated cut-off points at 10.07 ms and 15.47 ms for T2* in the determination of HIO with accuracy 88 %/88 %, sensitivity 84 %/89.5 % and specificity 100 %/83 %. MRI correctly classified 20 patients (80 %). All patients with HIO only had decreased T1 and T2* relaxation times. There was a significant difference in T1 between patients with HIO only and patients with HIO and steatohepatitis (P = 0.018).
MRI-based T2* relaxation diagnoses HIO very accurately, even at low iron concentrations. Important additional information may be obtained by the combination of T1 and T2* mapping. It is a rapid, non-invasive, accurate and reproducible technique for validating the evidence of even low hepatic iron concentrations.
• Hepatic iron overload causes fibrosis, cirrhosis and increases hepatocellular carcinoma risk.
• MRI detects iron because of the field heterogeneity generated by haemosiderin.
• T2* relaxation is very accurate in diagnosing hepatic iron overload.
• Additional information may be obtained by T1 and T2* mapping.
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- Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload
Volume 22, Issue 11 , pp 2478-2486
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- Magnetic resonance imaging
- Fatty liver
- Hepatic iron
- Iron overload
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- Author Affiliations
- 1. Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria
- 2. Department of Internal Medicine, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria
- 3. Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim – Heidelberg University, Mannheim, Germany