European Radiology

, Volume 22, Issue 10, pp 2201–2210

Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI

  • B. Nicolas Bloch
  • Elizabeth M. Genega
  • Daniel N. Costa
  • Ivan Pedrosa
  • Martin P. Smith
  • Herbert Y. Kressel
  • Long Ngo
  • Martin G. Sanda
  • William C. DeWolf
  • Neil M. Rofsky
Magnetic Resonance

DOI: 10.1007/s00330-012-2475-5

Cite this article as:
Bloch, B.N., Genega, E.M., Costa, D.N. et al. Eur Radiol (2012) 22: 2201. doi:10.1007/s00330-012-2475-5

Abstract

Objectives

To assess the value of dynamic contrast-enhanced (DCE) combined with T2-weighted (T2W) endorectal coil (ERC) magnetic resonance imaging (MRI) at 3 T for determining extracapsular extension (ECE) of prostate cancer.

Methods

In this IRB-approved study, ERC 3-T MRI of the prostate was performed in 108 patients before radical prostatectomy. T2W fast spin-echo and DCE 3D gradient echo images were acquired. The interpretations of readers with varied experience were analysed. MRI-based staging results were compared with radical prostatectomy histology. Descriptive statistics were generated for prediction of ECE and staging accuracies were determined by the area under the receiver-operating characteristic curve.

Results

The overall sensitivity, specificity, positive predictive value and negative predictive value for ECE were 75 %, 92 %, 79 % and 91 %, respectively. Diagnostic accuracy for staging was 86 %, 80 % and 91 % for all readers, experienced and less experienced readers, respectively.

Conclusions

ERC 3-T MRI of the prostate combining DCE and T2W imaging is an accurate pretherapeutic staging tool for assessment of ECE in clinical practice across varying levels of reader experience.

Key Points

Endorectal coil (ERC) magnetic resonance imaging is widely used for imaging prostatic disease.

ERC 3-T MRI is reasonably accurate for local prostate cancer staging.

High diagnostic accuracy is achievable across different levels of reader experience.

MRI facilitates therapeutic decisions in patients with prostate cancer.

Keywords

Prostate cancer Magnetic resonance imaging Cancer staging Clinical interpretation Learning curve 

Abbreviations

AJCC

American Joint Committee on Cancer

AUC

area under the receiver-operating characteristic curve

DCE

dynamic contrast-enhanced

DWI

diffusion-weighted imaging

ECE

extracapsular extension

ERC

endorectal coil

IRB

institutional review board

NIH

National Institute of Health

NPV

negative predictive value

PPV

positive predictive value

T2W

T2-weighted

3 T

3 tesla

3TP

three-time-point

Copyright information

© European Society of Radiology 2012

Authors and Affiliations

  • B. Nicolas Bloch
    • 1
    • 5
  • Elizabeth M. Genega
    • 2
  • Daniel N. Costa
    • 1
    • 7
  • Ivan Pedrosa
    • 1
    • 7
  • Martin P. Smith
    • 1
  • Herbert Y. Kressel
    • 1
  • Long Ngo
    • 3
  • Martin G. Sanda
    • 4
  • William C. DeWolf
    • 4
  • Neil M. Rofsky
    • 1
    • 6
  1. 1.Department of RadiologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  2. 2.Department of PathologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  3. 3.Department of General MedicineBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  4. 4.Department of Division of UrologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  5. 5.Department of RadiologyBoston Medical Center and Boston UniversityBostonUSA
  6. 6.Department of RadiologyUniversity of Texas Southwestern Medical CenterDallasUSA
  7. 7.Department of RadiologyUniversity of Texas Southwestern Medical CenterDallasUSA

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