European Radiology

, Volume 22, Issue 5, pp 1114–1121

Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) imaging of multiple myeloma: initial clinical efficiency results

  • Miyuki Takasu
  • Chihiro Tani
  • Yasuko Sakoda
  • Miho Ishikawa
  • Keizo Tanitame
  • Shuji Date
  • Yuji Akiyama
  • Akira Sakai
  • Hideki Asaoku
  • Toshio Kajima
  • Kazuo Awai
Magnetic Resonance

DOI: 10.1007/s00330-011-2351-8

Cite this article as:
Takasu, M., Tani, C., Sakoda, Y. et al. Eur Radiol (2012) 22: 1114. doi:10.1007/s00330-011-2351-8

Abstract

Objectives

To evaluate the effectiveness of the iterative decomposition of water and fat with echo asymmetric and least-squares estimation (IDEAL) MRI to quantify tumour infiltration into the lumbar vertebrae in myeloma patients without visible focal lesions.

Methods

The lumbar spine was examined with 3 T MRI in 24 patients with multiple myeloma and in 26 controls. The fat-signal fraction was calculated as the mean value from three vertebral bodies. A post hoc test was used to compare the fat-signal fraction in controls and patients with monoclonal gammopathy of undetermined significance (MGUS), asymptomatic myeloma or symptomatic myeloma. Differences were considered significant at P < 0.05. The fat-signal fraction and β2-microglobulin-to-albumin ratio were entered into the discriminant analysis.

Results

Fat-signal fractions were significantly lower in patients with symptomatic myelomas (43.9 ±19.7%, P < 0.01) than in the other three groups. Discriminant analysis showed that 22 of the 24 patients (92%) were correctly classified into symptomatic or non-symptomatic myeloma groups.

Conclusions

Fat quantification using the IDEAL sequence in MRI was significantly different when comparing patients with symptomatic myeloma and those with asymptomatic myeloma. The fat-signal fraction and β2-microglobulin-to-albumin ratio facilitated discrimination of symptomatic myeloma from non-symptomatic myeloma in patients without focal bone lesions.

Key Points

• A new magnetic resonance technique (IDEAL) offers new insights in multiple myeloma.

• Fat-signal fractions were lower in patients with symptomatic myelomas than in those with asymptomatic myelomas.

• The β2-microglobulin-to-albumin ratio also aided discrimination of symptomatic myeloma.

• The fat-signal fraction may provide information about the myeloma cell mass.

Keywords

Multiple myeloma Magnetic resonance imaging Bone marrow IDEAL Spine 

Supplementary material

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Supplemental Material 1(DOC 29 kb)
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Supplemental Material Fig. 1a

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Copyright information

© European Society of Radiology 2011

Authors and Affiliations

  • Miyuki Takasu
    • 1
  • Chihiro Tani
    • 1
  • Yasuko Sakoda
    • 1
  • Miho Ishikawa
    • 1
  • Keizo Tanitame
    • 1
  • Shuji Date
    • 1
  • Yuji Akiyama
    • 1
  • Akira Sakai
    • 2
  • Hideki Asaoku
    • 3
  • Toshio Kajima
    • 4
  • Kazuo Awai
    • 1
  1. 1.Department of Diagnostic Radiology, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimashiJapan
  2. 2.Department of Hematology and Oncology, Research Institute for Radiation Biology and MedicineHiroshima UniversityHiroshimashiJapan
  3. 3.Department of HematologyHiroshima Red Cross Hospital & Atomic-bomb Survivors HospitalHiroshimashiJapan
  4. 4.Kajima ClinicHiroshimakenJapan

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