European Radiology

, Volume 22, Issue 2, pp 350–357

Diagnostic performance of a near-infrared breast imaging system as adjunct to mammography versus X-ray mammography alone

  • F. Collettini
  • J. C. Martin
  • F. Diekmann
  • E. Fallenberg
  • F. Engelken
  • S. Ponder
  • T. J. Kroencke
  • B. Hamm
  • A. Poellinger
Experimental

DOI: 10.1007/s00330-011-2276-2

Cite this article as:
Collettini, F., Martin, J.C., Diekmann, F. et al. Eur Radiol (2012) 22: 350. doi:10.1007/s00330-011-2276-2

Abstract

Objectives

Radiologist reader performance for breast cancer detection using mammography plus Near-Infrared Breast Imaging (NIBI) was compared with mammography alone.

Methods

Two hundred seventy-six consecutive patients with suspected breast lesions underwent both mammography and NIBI. Four blinded radiologists independently first reviewed the mammograms alone. Readers subsequently reviewed the mammograms in combination with NIBI. The diagnostic benefit of NIBI as an adjunct to mammography was determined by performing receiver operating characteristics (ROC) analyses for each reader based on BI-RADS categories (Breast Imaging Reporting and Data System) and LOS (level of suspicion) scores. Additionally, a multireader-multicase (ROC) analysis of variance (ANOVA) was carried out.

Results

For the LOS-based analysis, the combination of mammography and NIBI resulted in a slightly larger area under the curve (AUC) for all four readers. The analysis based on BI-RADS categories also demonstrated a slight increase in AUC for three readers for the combination of mammography and NIBI compared with mammography alone. For the fourth reader, AUC was smaller for the combination compared with mammography alone. Neither for the separate ROC-analyses nor for the ANOVA, significant differences between the two methods were obtained.

Conclusions

The combination of mammography and NIBI did not perform significantly better than mammography alone.

Key Points

  • The intrinsic contrast provided by optical breast imaging may be inadequate

  • We found slightly (but nonsignificant) higher accuracy for optical imaging and mammography compared with mammography alone.

  • Contrast agents might be necessary to improve the performance of optical breast imaging

Keywords

Optical tomographyLasersBreast neoplasmsROC analysisMammography

Copyright information

© European Society of Radiology 2011

Authors and Affiliations

  • F. Collettini
    • 1
  • J. C. Martin
    • 1
  • F. Diekmann
    • 1
  • E. Fallenberg
    • 1
  • F. Engelken
    • 1
  • S. Ponder
    • 2
  • T. J. Kroencke
    • 1
  • B. Hamm
    • 1
  • A. Poellinger
    • 1
    • 3
  1. 1.Department of RadiologyCharité Universitätsmedizin BerlinBerlinGermany
  2. 2.Imaging Diagnostic Systems, IncFort LauderdaleUSA
  3. 3.Department of RadiologyCharité, Universitätsmedizin BerlinBerlinGermany