European Radiology

, Volume 21, Issue 2, pp 426–433

Diffusion tensor imaging and fibre tracking in cervical spondylotic myelopathy

  • Jean-François Budzik
  • Vincent Balbi
  • Vianney Le Thuc
  • Alain Duhamel
  • Richard Assaker
  • Anne Cotten
Musculoskeletal

DOI: 10.1007/s00330-010-1927-z

Cite this article as:
Budzik, J., Balbi, V., Le Thuc, V. et al. Eur Radiol (2011) 21: 426. doi:10.1007/s00330-010-1927-z

Abstract

Objectives

To (1) obtain microstructural parameters (Fractional Anisotropy: FA, Mean Diffusivity: MD) of the cervical spinal cord in patients suffering from cervical spondylotic myelopathy (CSM) using tractography, (2) to compare DTI parameters with the clinical assessment of these patients (3) and with information issued from conventional sequences.

Methods

DTI was performed on 20 symptomatic patients with cervical spondylotic myelopathy, matched with 15 volunteers. FA and MD were calculated from tractography images at the C2-C3 level and compressed level in patients and at the C2-C3 and C4-C7 in controls. Patients were clinically evaluated using a self-administered questionnaire.

Results

The FA values of patients were significantly lower at the compressed level than the FA of volunteers at the C4-C7 level. A significant positive correlation between FA at the compressed level and clinical assessment was demonstrated. Increased signal intensity on T2-weighted images did not correlate either with FA or MD values, or with any of the clinical scores.

Conclusion

FA values were significantly correlated with some of the patients’ clinical scores. High signal intensity of the spinal cord on T2 was not correlated either with the DTI parameters or with the clinical assessment, suggesting that FA is more sensitive than T2 imaging.

Keywords

Diffusion tensor imagingCervical spondylosisTractographyClinical correlationFractional nisotropy

Abbreviation

DTI

Diffusion Tensor Imaging

DT

Diffusion Tensor

CSM

Cervical Spondylotic Myelopathy

MR

Magnetic Resonance

FA

Fractional Anisotropy

MD

Mean Diffusivity

ADC

Apparent Diffusion Coefficient

JOACMEQ

Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire

ROI

Region of Interest

DTI-FT

Fibre Tracking (with Diffusion Tensor Imaging)

Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Jean-François Budzik
    • 1
  • Vincent Balbi
    • 1
  • Vianney Le Thuc
    • 1
  • Alain Duhamel
    • 2
  • Richard Assaker
    • 3
  • Anne Cotten
    • 1
  1. 1.Service de Radiologie et d’Imagerie MusculosquelettiqueHôpital Roger SalengroLilleFrance
  2. 2.Université de LilleLilleFrance
  3. 3.Département de NeurochirurgieHôpital Roger SalengroLille CedexFrance