European Radiology

, Volume 20, Issue 12, pp 2925–2932

Regional impairment of 18F-FDG uptake in the cervical spinal cord in patients with monosegmental chronic cervical myelopathy

Authors

  • Frank Willi Floeth
    • Department of NeurosurgeryHeinrich Heine University
    • Department of Spine and PainSt. Vinzenz Hospital
  • Gabriele Stoffels
    • Institute of Neuroscience and MedicineForschungszentrum Jülich
  • Jörg Herdmann
    • Department of NeurosurgeryHeinrich Heine University
    • Department of Spine and PainSt. Vinzenz Hospital
  • Paul Jansen
    • Central Institute of Applied MathematicsForschungszentrum Jülich
  • Wolfgang Meyer
    • Central Institute of Applied MathematicsForschungszentrum Jülich
  • Hans-Jakob Steiger
    • Department of NeurosurgeryHeinrich Heine University
    • Institute of Neuroscience and MedicineForschungszentrum Jülich
    • Institute of Neuroscience and Medicine, INM-4 (Brain Imaging Physics)Forschungszentrum Jülich
Head and Neck

DOI: 10.1007/s00330-010-1877-5

Cite this article as:
Floeth, F.W., Stoffels, G., Herdmann, J. et al. Eur Radiol (2010) 20: 2925. doi:10.1007/s00330-010-1877-5

Abstract

Objective

The aim of this preliminary report was to assess glucose metabolism in the cervical spine of patients with chronic compressive myelopathy by using FDG PET.

Methods

Ten patients with monosegmental chronic degenerative stenosis and local cord compression of the upper/middle cervical spine with signs of myelopathy on MRI and 10 control patients without known cervical abnormalities were investigated by FDG PET. Maximum standardised uptake values (SUVmax) were measured at all levels of the cervical spine (C1–C7).

Results

While the controls showed the typical pattern of homogeneous linear FDG uptake along the entire cervical cord, the patients with chronic compressive myelopathy had a normal glucose utilisation only above the level of stenosis and a significant decrease in FDG uptake below their individual level of cord compression. This may be caused by atrophy of anterior grey horn cells and the loss of glucose-consuming neurons below the level of cord compression.

Conclusion

FDG PET of the spine of patients with chronic compressive myelopathy may be helpful to determine the stage and severity of cervical myelopathy.

Keywords

FDG PETCervical spinal cordCervical myelopathyDegenerative spinal stenosis

Copyright information

© European Society of Radiology 2010