European Radiology

, Volume 20, Issue 8, pp 1812–1821

Radiofrequency ablation of renal tumours: diagnostic accuracy of contrast-enhanced ultrasound for early detection of residual tumour

Authors

  • Christine Hoeffel
    • CHU de Reims, Hôpital Robert Debré, Pôle d’imagerieService de Radiologie
  • Maud Pousset
    • Département de Biostatistiques, Hôpital NeckerUniversité Paris-Descartes, AP-HP
  • Marc-Olivier Timsit
    • Service d’urologie, Hôpital NeckerUniversité Paris-Descartes, AP-HP
  • Caroline Elie
    • Département de Biostatistiques, Hôpital NeckerUniversité Paris-Descartes, AP-HP
  • Arnaud Méjean
    • Service d’urologie, Hôpital NeckerUniversité Paris-Descartes, AP-HP
  • Samuel Merran
    • Service d’imagerie médicaleFédération mutualiste parisienne
  • François Tranquart
    • Bracco Research
  • Ahmed Khairoune
    • Service de radiologie adultes, Hôpital NeckerUniversité Paris-Descartes, AP-HP
  • Dominique Joly
    • Service de Néphrologie, Hôpital NeckerUniversité Paris-Descartes, AP-HP
  • Stéphane Richard
    • Centre Pilote Tumeurs rares INCa, AP-HPService d’urologie, Hôpital de Bicêtre
    • Service de NéphrologieHôpital Necker
    • Génétique oncologique, CNRS FRE 2939, Faculté de médecine Paris-SudLe Kremlin-Bicêtre et Institut de Cancérologie Gustave Roussy
  • Olivier Hélénon
    • Service de radiologie adultes, Hôpital NeckerUniversité Paris-Descartes, AP-HP
    • Service de radiologie adultes, Hôpital NeckerUniversité Paris-Descartes, AP-HP
Urogenital

DOI: 10.1007/s00330-010-1742-6

Cite this article as:
Hoeffel, C., Pousset, M., Timsit, M. et al. Eur Radiol (2010) 20: 1812. doi:10.1007/s00330-010-1742-6
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Abstract

Objective

To evaluate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in the early detection of residual tumour after radiofrequency ablation (RFA) of renal tumours.

Methods

Patients referred to our institution for RFA of renal tumours prospectively underwent CEUS and computed tomography (CT) or magnetic resonance imaging (MRI) before, within 1 day and 6 weeks after treatment. Identification of residual tumour was assessed by three blinded radiologists. Reference standard was CT/MRI performed at least 1 year after RFA.

Results

A total of 66 renal tumours in 43 patients (median age 62 years; range 44–71.5) were studied. Inter-reader agreement (κ value) was 0.84 for CEUS. Prevalence of residual disease was 19%. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), respectively, were as follows: 64% [confidence interval (CI) 39–84], 98% [CI 91–100], 82% [CI 52–95] and 92% [CI 83–97] on 24-h CEUS; 79% [CI 52–92], 100% [CI 94–100], 100% [CI 74–100] and 95% [CI 87–100] on 6-week CEUS; 79% [CI 52–92], 95% [CI 86–98], 79% [CI 52–92] and 95% [CI 86–98] on 24-h CT/MRI; and 100% [CI 72–100], 98% [CI 90–100], 91% [CI 62–98] and 100% [CI 93–100] on 6-week CT/MRI.

Conclusion

CEUS has high specificity for the early diagnosis of residual tumour after renal RFA.

Keywords

KidneyTumourRadiofrequency ablationContrast-enhanced ultrasoundCTMRI

Copyright information

© European Society of Radiology 2010