European Radiology

, Volume 20, Issue 4, pp 941–948

Three-dimensional textural analysis of brain images reveals distributed grey-matter abnormalities in schizophrenia

  • Balaji Ganeshan
  • Kenneth A. Miles
  • Rupert C. D. Young
  • Christopher R. Chatwin
  • Hugh M. D. Gurling
  • Hugo D. Critchley
Computer Applications

DOI: 10.1007/s00330-009-1605-1

Cite this article as:
Ganeshan, B., Miles, K.A., Young, R.C.D. et al. Eur Radiol (2010) 20: 941. doi:10.1007/s00330-009-1605-1

Abstract

Objectives

Three-dimensional (3-D) selective- and relative-scale texture analysis (TA) was applied to structural magnetic resonance (MR) brain images to quantify the presence of grey-matter (GM) and white-matter (WM) textural abnormalities associated with schizophrenia.

Materials and methods

Brain TA comprised volume filtration using the Laplacian of Gaussian filter to highlight fine, medium and coarse textures within GM and WM, followed by texture quantification. Relative TA (e.g. ratio of fine to medium) was also computed. T1-weighted MR whole-brain images from 32 participants with diagnosis of schizophrenia (n = 10) and healthy controls (n = 22) were examined. Five patients possessed marker alleles (SZ8) associated with schizophrenia on chromosome 8 in the pericentriolar material 1 gene while the remaining five had not inherited any of the alleles (SZ0).

Results

Filtered fine GM texture (mean grey-level intensity; MGI) most significantly differentiated schizophrenic patients from controls (P = 0.0058; area under the receiver-operating characteristic curve = 0.809, sensitivity = 90%, specificity = 70%). WM measurements did not distinguish the two groups. Filtered GM and WM textures (MGI) correlated with total GM and WM volume respectively. Medium-to-coarse GM entropy distinguished SZ0 from controls (P = 0.0069) while measures from SZ8 were intermediate between the two.

Conclusions

3-D TA of brain MR enables detection of subtle distributed morphological features associated with schizophrenia, determined partly by susceptibility genes.

Keywords

3-D texture analysisStructural brainMagnetic resonance imaging (MRI)SchizophreniaPCM1 gene

Copyright information

© European Society of Radiology 2009

Authors and Affiliations

  • Balaji Ganeshan
    • 1
    • 2
  • Kenneth A. Miles
    • 1
  • Rupert C. D. Young
    • 2
  • Christopher R. Chatwin
    • 2
  • Hugh M. D. Gurling
    • 3
  • Hugo D. Critchley
    • 1
  1. 1.Clinical Imaging Sciences Centre, Brighton and Sussex Medical SchoolUniversity of Sussex, FalmerBrightonUK
  2. 2.Department of Engineering and DesignUniversity of Sussex, FalmerBrightonUK
  3. 3.Department of Mental Health SciencesUniversity College LondonLondonUK