Musculoskeletal

European Radiology

, Volume 20, Issue 2, pp 458-468

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard

  • Ahi S. IsseverAffiliated withDepartment of Radiology, Charité Campus Mitte, UniversitaetsmedizinDepartment of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of CaliforniaDepartment of Radiology, Charité Campus Mitte, Universitaetsmedizin Berlin Email author 
  • , Thomas M. LinkAffiliated withDepartment of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California
  • , Marie KentenichAffiliated withDepartment of Radiology, Charité Campus Mitte, UniversitaetsmedizinDepartment of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California
  • , Patrik RogallaAffiliated withDepartment of Radiology, Charité Campus Mitte, Universitaetsmedizin
  • , Andrew J. BurghardtAffiliated withDepartment of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California
  • , Galateia J. KazakiaAffiliated withDepartment of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California
  • , Sharmila MajumdarAffiliated withDepartment of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California
  • , Gerd DiederichsAffiliated withDepartment of Radiology, Charité Campus Mitte, UniversitaetsmedizinDepartment of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California

Abstract

Objectives

The aim of our study was to perform trabecular bone structure analysis with images from 64- and 320-slice multidetector computed tomography (MDCT) and to compare these with high-resolution peripheral computed tomography (HR-pQCT).

Materials and methods

Twenty human cadaver distal forearm specimens were imaged on a 64- and 320-slice MDCT system at 120 kVp, 200 mA and 135 kVp, 400 mA (in-plane pixel size 234 µm; slice thickness 500 µm). HR-pQCT imaging was performed at an isotropic voxel size of 41 µm. Bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp) were computed.

Results

MDCT-derived BV/TV and Tb.Sp were highly correlated (r = 0.92–0.96, p < 0.0001) with the corresponding HR-pQCT parameters. Tb.Th was the only structure measure that did not yield any significant correlation.

Conclusion

The 64- and 320-slice MDCT systems both perform equally well in depicting trabecular bone architecture. However, because of constrained resolutions accurate derivation of trabecular bone measures is limited to only a subset of microarchitectural parameters.

Keywords

320-slice MDCT HR-pQCT Osteoporosis Structure analysis Trabecular bone