European Radiology

, Volume 19, Issue 3, pp 591–598

ACCURATUM: improved calcium volume scoring using a mesh-based algorithm—a phantom study

  • Stefan C. Saur
  • Hatem Alkadhi
  • Lotus Desbiolles
  • Gábor Székely
  • Philippe C. Cattin
Cardiac

DOI: 10.1007/s00330-008-1181-9

Cite this article as:
Saur, S.C., Alkadhi, H., Desbiolles, L. et al. Eur Radiol (2009) 19: 591. doi:10.1007/s00330-008-1181-9

Abstract

To overcome the limitations of the classical volume scoring method for quantifying coronary calcifications, including accuracy, variability between examinations, and dependency on plaque density and acquisition parameters, a mesh-based volume measurement method has been developed. It was evaluated and compared with the classical volume scoring method for accuracy, i.e., the normalized volume (measured volume/ground-truthed volume), and for variability between examinations (standard deviation of accuracy). A cardiac computed-tomography (CT) phantom containing various cylindrical calcifications was scanned using different tube voltages and reconstruction kernels, at various positions and orientations on the CT table and using different slice thicknesses. Mean accuracy for all plaques was significantly higher (p < 0.0001) for the proposed method (1.220 ± 0.507) than for the classical volume score (1.896 ± 1.095). In contrast to the classical volume score, plaque density (p = 0.84), reconstruction kernel (p = 0.19), and tube voltage (p = 0.27) had no impact on the accuracy of the developed method. In conclusion, the method presented herein is more accurate than classical calcium scoring and is less dependent on tube voltage, reconstruction kernel, and plaque density.

Keywords

Coronary calciumVolumeComputed tomography

Supplementary material

330_2008_1181_MOESM1_ESM.doc (44 kb)
Table 1The mean Agatston score (±standard deviation) and mean calcium mass (±standard deviation) were computed for each plaque within the various training and evaluation data sets. (DOC 43.5 KB)

Copyright information

© European Society of Radiology 2008

Authors and Affiliations

  • Stefan C. Saur
    • 1
  • Hatem Alkadhi
    • 2
    • 4
  • Lotus Desbiolles
    • 2
  • Gábor Székely
    • 1
  • Philippe C. Cattin
    • 1
    • 3
  1. 1.Computer Vision Laboratory, ETH ZurichZurichSwitzerland
  2. 2.Institute of Diagnostic RadiologyUniversity Hospital ZurichZurichSwitzerland
  3. 3.CMBEUniversity of BaselBaselSwitzerland
  4. 4.Department of Medical Radiology, Institute of Diagnostic RadiologyUniversity Hospital ZurichZurichSwitzerland