European Radiology

, 17:2926

Optical tomography of the neonatal brain


DOI: 10.1007/s00330-007-0659-1

Cite this article as:
Hebden, J.C. & Austin, T. Eur Radiol (2007) 17: 2926. doi:10.1007/s00330-007-0659-1


A new method of assessing neurological function and pathology in the newborn infant is being developed based on the transmission of near-infrared light across the brain. Absorption by blood over a range of wavelengths reveals a strong dependency on oxygenation status, and measurements of transmitted light enable the spatial variation in the concentrations of the oxygenated and de-oxygenated forms of hemoglobin to be derived. Optical tomography has so far provided static three-dimensional maps of blood volume and oxygenation as well as dynamic images revealing the brain’s response to sensory stimulation and global hemodynamic changes. The imaging modality is being developed as a safe and non-invasive tool that can be utilized at the cotside in intensive care. Optical tomography of the healthy infant brain is also providing a means of studying neurophysiological processes during early development and the potential consequences of prematurity.


Optical imagingBrain imagingNeonatal

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Department of Medical Physics & BioengineeringUniversity College LondonLondonUK
  2. 2.Department of Paediatrics & Child HealthUniversity College LondonLondonUK