European Radiology

, Volume 17, Issue 1, pp 87–96

Diagnostic accuracy of 16-slice multidetector-row CT for detection of in-stent restenosis vs detection of stenosis in nonstented coronary arteries

  • Joelle M. Kefer
  • Emmanuel Coche
  • Jean-Louis J. Vanoverschelde
  • Bernhard L. Gerber

DOI: 10.1007/s00330-006-0291-5

Cite this article as:
Kefer, J.M., Coche, E., Vanoverschelde, JL.J. et al. Eur Radiol (2007) 17: 87. doi:10.1007/s00330-006-0291-5


The purpose of this study was to assess the diagnostic accuracy of 16-slice multidetector-row computed tomography (MDCT) for detecting in-stent restenosis. Fifty patients with 69 previously implanted coronary stents underwent 16-slice MDCT before quantitative coronary angiography (QCA). Diagnostic accuracy of MDCT for detection of in-stent restenosis defined as >50% lumen diameter stenosis (DS) in stented and nonstented coronary segments >1.5-mm diameter was computed using QCA as reference. According to QCA, 18/69 (25%) stented segments had restenosis. In addition, 33/518 (6.4%) nonstented segments had >50% DS. In-stent restenosis was correctly identified on MDCT images in 12/18 stents, and absence of restenosis was correctly identified in 50/51 stents. Stenosis in native coronary arteries was correctly identified in 22/33 segments and correctly excluded in 482/485 segments. Thus, sensitivity (67% vs 67% p=1.0), specificity (98% vs 99%, p=0.96) and overall diagnostic accuracy (90% vs 97%, p=0.68) was similarly high for detecting in-stent restenosis as for detecting stenosis in nonstented coronary segments. MDCT has similarly high diagnostic accuracy for detecting in-stent restenosis as for detecting coronary artery disease in nonstented segments. This suggests that MDCT could be clinically useful for identification of restenosis in patients after coronary stenting.


Multidetector CTStentRestenosisCoronary angioplasty



coronary artery disease


diameter stenosis


multidetector-row computed tomography


minimal lumen diameter


magnetic resonance imaging


New York Heart Association


quantitative coronary angiography


reference vessel diameter

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Joelle M. Kefer
    • 1
  • Emmanuel Coche
    • 2
  • Jean-Louis J. Vanoverschelde
    • 1
  • Bernhard L. Gerber
    • 1
  1. 1.Department of CardiologyCliniques Universitaires St. Luc UCLBrusselsBelgium
  2. 2.Department of RadiologyCliniques Universitaires St. Luc UCLBrusselsBelgium