European Radiology

, Volume 16, Issue 9, pp 2067–2073

Higher sensitivity in the detection of inflammatory brain lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis using high field MRI: an intraindividual comparison of 1.5 T with 3.0 T

  • Mike P. Wattjes
  • Götz G. Lutterbey
  • Michael Harzheim
  • Jürgen Gieseke
  • Frank Träber
  • Luisa Klotz
  • Thomas Klockgether
  • Hans H. Schild
Neuro

DOI: 10.1007/s00330-006-0195-4

Cite this article as:
Wattjes, M.P., Lutterbey, G.G., Harzheim, M. et al. Eur Radiol (2006) 16: 2067. doi:10.1007/s00330-006-0195-4

Abstract

The purpose of this study was to determine the sensitivities in the detection of inflammatory lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis at 3.0 T and 1.5 T. MR imaging of 40 patients at both field strengths was performed in separate sessions including contiguous axial slices of T2 turbo spin-echo (T2 TSE), fluid-attenuated-inversion-recovery (FLAIR) and pre- and postcontrast T1 spin-echo (T1 SE). Inflammatory lesions >3 mm in size were counted and categorized according to their anatomic location. Lesion conspicuity was assessed on a five-point scale. At 3.0 T, 13% more white matter lesions could be identified on the FLAIR sequence and on the T2 TSE sequence. Compared to 1.5 T 7.5% more contrast-enhancing lesions were detected at 3.0 T. The higher detection rate at 3.0 T was significant for the infratentorial (p=0.02) and juxtacortical (p<0.01) region on the FLAIR as well as for the infratentorial (p=0.03), juxtacortical (p=0.02) and periventricular (p=0.03) region on the T2 TSE sequence. The lesion conspicuity was significantly better at 3.0 T for FLAIR and T2 TSE sequences (p<0.01; p=0.01). In conclusion, high-field MRI at 3.0 T provides a significantly higher detection rate of inflammatory brain lesions especially in the infratentorial, juxtacortical and periventricular anatomic region.

Keywords

High-field MRIMultiple sclerosisClinically isolated syndromeMagnetic field strength

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Mike P. Wattjes
    • 1
  • Götz G. Lutterbey
    • 1
  • Michael Harzheim
    • 2
  • Jürgen Gieseke
    • 1
    • 3
  • Frank Träber
    • 1
  • Luisa Klotz
    • 2
  • Thomas Klockgether
    • 2
  • Hans H. Schild
    • 1
  1. 1.Department of RadiologyUniversity of BonnBonnGermany
  2. 2.Department of NeurologyUniversity of BonnBonnGermany
  3. 3.Philips Medical SystemsBestThe Netherlands