European Radiology

, Volume 15, Issue 9, pp 1969–1977

MRI for short-term follow-up of acute pulmonary embolism. Assessment of thrombus appearance and pulmonary perfusion: a feasibility study

  • Alexander Kluge
  • Tibo Gerriets
  • Uwe Lange
  • George Bachman
Chest

DOI: 10.1007/s00330-005-2760-7

Cite this article as:
Kluge, A., Gerriets, T., Lange, U. et al. Eur Radiol (2005) 15: 1969. doi:10.1007/s00330-005-2760-7

Abstract

Tha aim of this study was to demonstrate the feasibility of MRI for short-term follow-up examinations in patients with acute pulmonary embolism (PE), and to assess temporal changes of pulmonary perfusion and thrombus characteristics that may be helpful in determining thrombus age. Thirty-three patients (15 female, 18 male, mean age 59.4 years) with acute PE were examined initially and 1 week later using both 16-row computed tomography (CT) and MRI with magnetic resonance angiography (MRA), real-time MRI and magnetic resonance (MR) pulmonary perfusion imaging. MRA and MR pulmonary perfusion used contrast-enhanced 3D flash sequences, and real-time MRI used true fast imaging with steady-state precession sequences (repetition time/echo time 3.1/1.5, bandwidth 975 Hz, 256 matrix size, acquisition time 0.4 s per image) in three orthogonal planes. Follow-up examinations were feasible for all patients. Diagnosis of PE was concordant between MRI and CT in all patients. The signal intensity of embolic material increased after 1 week for real-time MRI [132±5 vs. 232±22 (standard error of the mean), p<0.001], but not significantly for MRA. MR pulmonary perfusion of areas affected by PE increased (area under the curve initially 9.6±7.4, at follow-up 40.7±7.6, p<0.001). A decreasing time-to-peak in normal lung areas (15.7±0.96 and 13.2±0.55, respectively, p<0.05) indicated systemic circulatory effects of PE, and subsiding pulmonary artery obstruction improved arterial inflow for the entire lung. Follow-up examinations of patients with acute PE are feasible with MRI, and a relation between thrombus appearance and thrombus age can be implied.

Keywords

Pulmonary embolismMagnetic resonance perfusion imagingMagnetic resonance angiography

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Alexander Kluge
    • 1
  • Tibo Gerriets
    • 1
  • Uwe Lange
    • 1
    • 2
  • George Bachman
    • 1
  1. 1.Department of Diagnostic RadiologyKerckhoff Heart CenterBad NauheimGermany
  2. 2.Department of RheumatologyKerckhoff Heart CenterBad NauheimGermany