European Radiology

, Volume 16, Issue 4, pp 827–836

Scarred myocardium imposes additional burden on remote viable myocardium despite a reduction in the extent of area with late contrast MR enhancement


    • Department of RadiologyUniversity of California
  • Randall J. Lee
    • Department of MedicineUniversity of California
  • Oliver Weber
    • Department of RadiologyUniversity of California
  • Loi Do
    • Department of RadiologyUniversity of California
  • Alastair Martin
    • Department of RadiologyUniversity of California
  • Philip Ursell
    • Department of PathologyUniversity of California
  • David Saloner
    • Department of RadiologyUniversity of California
  • Charles B. Higgins
    • Department of RadiologyUniversity of California

DOI: 10.1007/s00330-005-0052-x

Cite this article as:
Saeed, M., Lee, R.J., Weber, O. et al. Eur Radiol (2006) 16: 827. doi:10.1007/s00330-005-0052-x


Magnetic resonance imaging (MRI) can simultaneously detect and quantify myocardial dysfunction and shrinkage in contrast-enhanced areas postinfarction. This ability permits the investigation of our hypothesis that transformation of infracted myocardium to scarred tissue imposes additional burdens on peri-infarcted and remote myocardium. Pigs (n=8) were subjected to reperfused infarction. Gd-DOTA-enhanced inversion recovery gradient echo sequence (IR-GRE) imaging was performed 3 days and 8 weeks postinfarction. Global and regional left ventricular (LV) function was evaluated by cine MRI. Triphenyltetrazolium chloride (TTC) stain was used to delineate infarction while hematoxylin and eosin (H & E) and Masson’s trichrome stains were used to characterize remodeled myocardium. Late contrast-enhanced MRIs showed a decrease in the extent of enhanced areas from 17±2% at 3 days to13±1% LV mass at 8 weeks. TTC infarction size was 12±1% LV mass. Cine MRIs showed expansion in dysfunctional area due to unfavorable remodeling, ischemia, or strain. Ejection fraction was reduced in association with increased end-diastolic and end-systolic volumes. Scarred myocardium contained collagen fibers and remodeled thick-walled vessels embedded in collagen. Sequential MRI showed greater LV dysfunction despite the shrinkage in extent of enhanced areas 2 months postinfarction. The integration of late enhancement and cine MRI incorporates anatomical and functional evaluation of remodeled hearts.


Myocardial infarctionCardiac functionMagnetic resonance imaging (MRI)MR contrast mediaLeft ventricular remodeling

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© Springer-Verlag 2005