Pediatric

European Radiology

, Volume 14, Issue 1, pp 59-72

Perfusion-weighted magnetic resonance imaging of the brain: techniques and application in children

  • Thierry A. G. M. HuismanAffiliated withDepartment of Radiology, Neuroradiology Section and MGH-NMR Center, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Radiology, University Children's Hospital Zurich Email author 
  • , A. Gregory SorensenAffiliated withDepartment of Radiology, Neuroradiology Section and MGH-NMR Center, Massachusetts General Hospital and Harvard Medical School

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Abstract

Perfusion-weighted magnetic resonance imaging (PWI) has been proposed as an attractive non-invasive tool for evaluating cerebral haemodynamics. Quantitative maps of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP) and various other haemodynamic parameters can be obtained. Recent advances in hard- and software made PWI available for clinical routine. Although PWI became common in adult neuroradiology, it remains challenging in pediatric neuroradiology. In this article, the different PWI techniques that render haemodynamic maps of the brain are presented and discussed. The normal developmental changes of the cerebral haemodynamics in children as measured by PWI are presented as well as the application of PWI in cerebral ischaemia, primary and secondary cerebral vasculopathies and in cerebral tumours.

Keywords

Perfusion-weighted imaging Dynamic susceptibility contrast imaging Haemodynamic parameter Children