European Radiology

, Volume 14, Issue 1, pp 14–20

Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT

  • Carlo Bartolozzi
  • Francescamaria Donati
  • Dania Cioni
  • Carlo Procacci
  • Giovanni Morana
  • Antonio Chiesa
  • Luigi Grazioli
  • Giorgio Cittadini
  • Giuseppe Cittadini
  • Andrea Giovagnoni
  • Giovanni Gandini
  • Jochen Maass
  • Riccardo Lencioni
Hepatobiliary–Pancreas

DOI: 10.1007/s00330-003-1966-9

Cite this article as:
Bartolozzi, C., Donati, F., Cioni, D. et al. Eur Radiol (2004) 14: 14. doi:10.1007/s00330-003-1966-9

Abstract

The aim of this study was to compare unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT in the detection of hepatic colorectal metastases. Forty-four patients with hepatic colorectal metastases were examined with unenhanced and MnDPDP-enhanced MRI and with unenhanced and contrast-enhanced spiral CT. The MR examination protocol included baseline T1-weighted spin-echo (SE), T1-weighted gradient-recalled-echo (GRE), and T2-weighted fast-SE sequences; and T1-weighted SE and T1-weighted GRE sequences obtained 30–60 min after administration of 0.5 µmol/kg (0.5 ml/kg) mangafodipir trisodium (MnDPDP). Images were interpreted by three blinded readers. Findings at CT and MRI were compared with those at intraoperative US, which were used as term of reference. Intraoperative US detected 128 metastases. In a lesion-by-lesion analysis, the overall detection rate was 71% (91 of 128) for spiral CT, 72% (92 of 128) for unenhanced MRI, and 90% (115 of 128) for MnDPDP-enhanced MRI. MnDPDP-enhanced MRI was more sensitive than either unenhanced MRI (p<0.0001) or spiral CT (p=0.0007). In a patient-by-patient analysis, agreement with gold standard was higher for MnDPDP-enhanced MRI (33 of 44 cases) than for spiral CT (22 of 44 cases, p=0.0023) and unenhanced MRI (21 of 44 cases, p=0.0013). MnDPDP-enhanced MRI is superior to unenhanced MRI and spiral CT in the detection of hepatic colorectal metastases.

Keywords

Liver neoplasmsComputed tomographyMetastasesMagnetic resonanceContrast mediaMangafodipir trisodium

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Carlo Bartolozzi
    • 1
  • Francescamaria Donati
    • 1
  • Dania Cioni
    • 1
  • Carlo Procacci
    • 2
  • Giovanni Morana
    • 2
  • Antonio Chiesa
    • 3
  • Luigi Grazioli
    • 3
  • Giorgio Cittadini
    • 4
    • 4
  • Giuseppe Cittadini
    • 4
    • 4
  • Andrea Giovagnoni
    • 5
  • Giovanni Gandini
    • 6
  • Jochen Maass
    • 6
  • Riccardo Lencioni
    • 1
  1. 1.Department of RadiologyUniversity of PisaPisaItaly
  2. 2.Department of RadiologyUniversity of VeronaVeronaItaly
  3. 3.Department of RadiologyUniversity of BresciaBresciaItaly
  4. 4.Department of RadiologyUniversity of GenovaGenovaItaly
  5. 5.Department of RadiologyUniversity of AnconaAnconaItaly
  6. 6.Department of RadiologyUniversity of TorinoTorinoItaly