Rheumatology International

, Volume 20, Issue 5, pp 192–196

Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: a new marker for disease activity

Authors

  • Ritva Peltomaa
    • Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Kasarmikatu 11–13, 00130 Helsinki, Finland
  • Leena Paimela
    • Invalid Foundation, Tenholantie 10, 00280 Helsinki, Finland
  • Sheryl Harvey
    • Novadex Inc., 11526 Sorrento Valley Road Suite B, San Diego, CA 92121, USA
  • Tapani Helve
    • Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Kasarmikatu 11–13, 00130 Helsinki, Finland
  • Marjatta Leirisalo-Repo
    • Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Kasarmikatu 11–13, 00130 Helsinki, Finland
Original Article

DOI: 10.1007/s002960100115

Cite this article as:
Peltomaa, R., Paimela, L., Harvey, S. et al. Rheumatol Int (2001) 20: 192. doi:10.1007/s002960100115

Abstract.

YKL-40 is a newly discovered major secretory protein of human chondrocytes and synoviocytes. We measured serum levels of YKL-40 in 52 patients with early onset rheumatoid arthritis (RA) by enzyme-linked immunosorbent assay (ELISA) during a 2-year prospective follow-up, correlating values with laboratory and clinical variables and radiographic progression. Levels at baseline before antirheumatic therapy were significantly higher in patients than in healthy controls. The levels of YKL-40 correlated with laboratory and clinical markers of disease activity both at baseline and during follow-up. Baseline YKL-40 values correlated with baseline Larsen scores but did not predict radiographic progression. Baseline and mean YKL-40 values did not differ between fast and slow radiological progressions. Mean YKL-40 levels correlated with the number of swollen joints but were not predictors of radiographic progression. These results suggest that in early RA, serum YKL-40 is an inflammatory marker correlating with disease activity. However, its levels do not predict clinical course or radiographic progression.

YKL-40 Early rheumatoid arthritis

Copyright information

© Springer-Verlag 2001