Rheumatology International

, Volume 34, Issue 1, pp 141–143

Multiple sclerosis during adalimumab treatment in a case with ankylosing spondylitis

  • Uğur Uygunoğlu
  • Derya Uluduz
  • Koray Taşçılar
  • Sabahattin Saip
Short Communication

DOI: 10.1007/s00296-012-2625-8

Cite this article as:
Uygunoğlu, U., Uluduz, D., Taşçılar, K. et al. Rheumatol Int (2014) 34: 141. doi:10.1007/s00296-012-2625-8

Abstract

Ankylosing spondylitis is a chronic and progressive inflammatory disease involving the sacroiliac joints with HLA-B27 positivity in 85 % of the patients and radiologically evidence of sacroiliitis. It is associated with several extraarticular manifestations, but neurological complications are rare. Occurrence of multiple sclerosis in patients with ankylosing spondylitis has been reported in limited cases. Adalimumab, a TNF-α antagonist, offers a significant improvement in ankylosing spondylitis and is considered to be less immunogenic and more tolerable than other TNF-α blockers. A case of multiple sclerosis coexisted with HLA-B27 positive ankylosing spondylitis after treated with adalimumab was reported.

Keywords

Ankylosing spondylitisMultiple sclerosisAdalimumab

Supplementary material

296_2012_2625_MOESM1_ESM.doc (956 kb)
Picture IBrain MRI. A.B. Axial T2 weighted images show multiple foci of high signal intensity in the white matter of right cerebellar pedinculi and periventricular area. C. Enhancement of a lesion in the right cerebellar pedunculi on axial T1-weighted images after i.v. contrast administration. D. 3 months after the presentation of initial symptoms, gadolinium enhancement disappeared on axial T1-weighted images (DOC 955 kb)
296_2012_2625_MOESM2_ESM.doc (1.1 mb)
Picture II1 year follow up brain MRI. A- Axial image showS multiple foci of high signal intensity in the white matter of periventricular area. B and C. Enhancement of a lesion in the right posterior periventricular area on axial and sagiral images after i.v. contrast administration (DOC 1141 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Uğur Uygunoğlu
    • 1
    • 2
  • Derya Uluduz
    • 1
  • Koray Taşçılar
    • 2
  • Sabahattin Saip
    • 1
    • 2
  1. 1.Department of Neurology, Cerrahpasa Faculty of MedicineIstanbul UniversityIstanbulTurkey
  2. 2.Neurology Division, Department of Neurology, Cerrahpasa Faculty of MedicineIstanbul UniversityIstanbulTurkey