Rheumatology International

, Volume 33, Issue 6, pp 1443–1446

Follow-up of primary Sjogren’s syndrome patients presenting positive anti-cyclic citrullinated peptides antibody

  • Yang-Seon Ryu
  • Sung-Hwan Park
  • Jennifer Lee
  • Seung-Ki Kwok
  • Ji-Hyeon Ju
  • Ho-Youn Kim
  • Chan-Hong Jeon
Original Article

DOI: 10.1007/s00296-012-2572-4

Cite this article as:
Ryu, YS., Park, SH., Lee, J. et al. Rheumatol Int (2013) 33: 1443. doi:10.1007/s00296-012-2572-4
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Abstract

Anti-cyclic citrullinated peptide antibody (anti-CCP antibody) is very useful for the diagnosis of rheumatoid arthritis (RA) and is associated with articular erosions. The specificity of anti-CCP antibody in the diagnosis of RA has been reported to be about 95 %. Because of its higher specificity in RA, we assessed the clinical features of primary Sjogren’s syndrome (pSS) who were positive for anti-CCP antibody. We assessed the clinical features of 405 pSS patients. After 60 (range 7–98) months, 23 (5.6 %) patients previously diagnosed with pSS had progressed to RA. Comparing the anti-CCP positive group with the negative group, laboratory test results for anti-CCP titer and rheumatoid factor positivity with respect to clinical outcome and progression to RA, arthralgia and arthritis were significantly different. Multivariate regression analysis also showed that anti-CCP antibody titer was independently associated with progression to RA. The odds ratio of anti-CCP positivity in terms of progression to RA was 2.5 (95 % CI 1.7–3.7). Testing for anti-CCP antibody in pSS patients with arthritis may allow for the prediction of progression to RA.

Keywords

Anti-CCP antibodyPrimary Sjogren’s syndromeRheumatoid arthritis

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Yang-Seon Ryu
    • 1
  • Sung-Hwan Park
    • 2
  • Jennifer Lee
    • 2
  • Seung-Ki Kwok
    • 2
  • Ji-Hyeon Ju
    • 2
  • Ho-Youn Kim
    • 2
  • Chan-Hong Jeon
    • 1
  1. 1.Division of Rheumatology, Department of Internal MedicineSoonchunhyang University School of MedicineBucheonKorea
  2. 2.Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea