PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?
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- Bilge, N.Ş.Y., Kaşifoğlu, T. & Korkmaz, C. Rheumatol Int (2013) 33: 117. doi:10.1007/s00296-011-2280-5
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Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides are rare, but they can be triggered by chemicals, infections and drugs; among them, antithyroid drugs are common. Autoimmune disorders, such as vasculitis, are unusual, but serious complications of antithyroid therapy. Both propylthiouracil (PTU) and methimazole may induce ANCA-associated vasculitis. PTU-induced vasculitides may have different organ involvement patterns. Herein, we report four cases with ANCA-associated vasculitis with different clinical manifestations.