Short Communication

Rheumatology International

, Volume 32, Issue 10, pp 3315-3317

First online:

Drug-induced lupus in anti-TNF-alpha therapy and its treatment with rituximab

  • Juan C. DiazAffiliated withDepartment of Internal Medicine, CES University
  • , Santiago VallejoAffiliated withDepartment of Internal Medicine, CES University
  • , Carlos A. CañasAffiliated withRheumatology Unit, Fundación Valle del Lili Email author 

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We report three patients with rheumatoid arthritis (RA) who were treated with anti-TNF-α agents and who developed drug-induced lupus (DIL). Two of them received etanercept and the remainder adalimumab. We also present the favorable response observed with the withdrawal of the anti-TNF-alpha agents and the introduction of rituximab. Through this intervention, we observed a very good control of the activity of both DIL and RA without additional adverse reactions.


Rheumatoid arthritis Etanercept Adalimumab Drug-induced lupus Rituximab