Original Article

Rheumatology International

, Volume 32, Issue 9, pp 2863-2866

First online:

Pulmonary tuberculosis and tuberculous arthritis of knee joint associated with rheumatoid arthritis treated with anti-tumor necrosis factor (TNF)-alpha medication: a case report

  • Selim NalbantAffiliated withDepartment of Internal Medicine, Maltepe University Medical School Email author 
  • , Mustafa ÖzyurtAffiliated withDepartment of Microbiology, Gulhane Military Medical Academy, Haydarpasa Training Hospital
  • , Murat YıldırımAffiliated withDepartment of Internal Medicine, Gulhane Military Medical Academy, Haydarpasa Training Hospital
  • , Mesih KuskucuAffiliated withDepartment of Orthopedic Surgery, Gulhane Military Medical Academy, Haydarpasa Training Hospital

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Tuberculosis infection (TB) is one of the most important problems for the rheumatoid arthritis (RA) patients treated with anti-TNF agents. Pulmonary tuberculosis is the most common clinic form of the TB in these patients. However, tuberculosis arthritis is very rare. We present here a 72-year-old Caucasian woman with seropositive RA, treated with etanercept/adalimumab for the last 2 years, who presented with resistant knee pain and joint effusion. We believe that this treatment caused the tuberculosis in this patient, which is the most worried complication. Interestingly, tuberculosis was in the knee joint at this time.


Rheumatoid arthritis Anti-TNF agents Knee joint Tuberculosis