Rheumatology International

, Volume 32, Issue 8, pp 2523–2527

Dickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy

Authors

  • Seong-Ryul Kwon
    • Rheumatism CenterInha University Hospital
  • Mie-Jin Lim
    • Rheumatism CenterInha University Hospital
  • Chang-Hee Suh
    • Department of RheumatologyAjou University School of Medicine
  • Shin-Goo Park
    • Department of Occupation and Environmental MedicineInha University Hospital
  • Yeon-Sik Hong
    • Department of RheumatologySt. Mary’s Hospital
  • Bo-Young Yoon
    • Department of RheumatologyInje University Ilsan Paik Hospital
  • Hyoun-Ah Kim
    • Department of RheumatologyAjou University School of Medicine
  • Hyo-Jin Choi
    • Department of RheumatologyGachon School of Medicine, Gachon University of Medicine and Science
    • Rheumatism CenterInha University Hospital
Original Article

DOI: 10.1007/s00296-011-1981-0

Cite this article as:
Kwon, S., Lim, M., Suh, C. et al. Rheumatol Int (2012) 32: 2523. doi:10.1007/s00296-011-1981-0

Abstract

(1) To compare the serum levels of Dickkopf-1 (DKK-1) and bone biomarkers in patients with ankylosing spondylitis (AS) and healthy controls. (2) To examine the effects of anti-tumor necrosis factor-α (TNF-α) therapy for 3 months on bone biomarkers in patients with AS. We measured the levels of DKK-1, osteocalcin, osteoprotegerin, and C-terminal telopeptide of type I collagen (CTX-1) in patients with AS and in healthy controls at baseline and 3 months after initiating anti-TNF-α therapy in AS patients. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were also measured before and after anti-TNF-α therapy in AS patients. Serum levels of DKK-1 were significantly lower in the AS patients than in the controls (P < 0.0001). Osteocalcin and osteoprotegerin levels were significantly higher in the AS patients than in the controls (P < 0.0001). Serum levels of DKK-1 were not changed after the 3-month anti-TNF-α therapy. Osteocalcin level increased (P < 0.0001), osteoprotegerin level and BASDAI scores decreased (P = 0.025 and P < 0.0001, respectively) significantly after the 3-months anti-TNF-α therapy. Serum DKK-1 level was lower in patients with AS than in healthy controls and did not change after 3 months of anti-TNF-α therapy in the AS patients despite the marked improvement in BASDAI scores. These findings suggest the low serum DKK-1 level is related to the pathogenesis of new bone formation in AS, which is resistant to TNF-α blocking therapy.

Keywords

Dickkopf-1Ankylosing spondylitisTNF blockerOsteocalcinOsteoprotegerinCTX-1BASDAI

Copyright information

© Springer-Verlag 2011