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Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan

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Abstract

The purpose of this study was to determine whether toll-like receptor 9 (TLR9) gene polymorphisms were markers of susceptibility to or severity of systemic lupus erythematosus (SLE) in Taiwanese patients. The study included 211 healthy individuals and 167 Chinese patients with SLE. Polymorphisms of TLR9 [rs2066807 and rs187084 (−1486 T/C)] were typed from genomic DNA. The genotypes, allelic frequencies, and carriage rates were compared between patients with SLE and control subjects. The relationship between allelic frequencies and clinical manifestations of 167 patients with SLE was evaluated. There was no statistically significant difference in TLR9 (rs2066807) gene polymorphism, allelic frequency, and carriage rate between the SLE and control groups. However, for the genotype of TLR9 −1486 T/C (rs187084) polymorphism, there was a statistically significant difference between the SLE and the control groups (P < 0.001, χ2 = 15.9). Moreover, there was a significant association between the two groups in allelic frequency and carriage rate of the T allele (P < 0.001, χ2 = 18.5 and P < 0.01, χ2 = 8.06, respectively). We did not detect any association between the TLR9 genotype and the clinical or laboratory profiles in patients with SLE. The results suggest that the TLR9 −1486 T/C (rs187084), but not TLR9 (rs2066807), polymorphism is related to SLE in Taiwanese patients.

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Acknowledgments

This study was supported by a grant (DMR-97-022) from the China Medical University Hospital of Taiwan.

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Authors and Affiliations

  1. Division of Immunology and Rheumatology, China Medical University Hospital, Taichung, Taiwan

    Chung-Ming Huang & Po-Hao Huang

  2. Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

    Wen-Liang Huang

  3. Department of Medicine Genetics, China Medical University Hospital, No 2 Yuh Der Road, Taichung, Taiwan

    Ying-Ju Lin & Fuu-Jen Tsai

  4. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan

    Chung-Ming Huang

  5. College of Chinese Medicine, China Medical University, Taichung, Taiwan

    Fuu-Jen Tsai

  6. Taichung Asia University, Taichung, Taiwan

    Chang-Hai Tsai

  7. Foo Yin Institute of Technology, Kaohsiung, Taiwan

    Chi-Lan Chen

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  1. Chung-Ming Huang
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  2. Po-Hao Huang
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  3. Chi-Lan Chen
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  4. Ying-Ju Lin
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  5. Chang-Hai Tsai
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  7. Fuu-Jen Tsai
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Corresponding author

Correspondence to Fuu-Jen Tsai.

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Huang, CM., Huang, PH., Chen, CL. et al. Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan. Rheumatol Int 32, 2105–2109 (2012). https://doi.org/10.1007/s00296-011-1925-8

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  • DOI: https://doi.org/10.1007/s00296-011-1925-8

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