Rheumatology International

, Volume 31, Issue 11, pp 1433–1437

Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis

  • Dongsheng Hao
  • Ming Li
  • Zhihong Wu
  • Yuanhui Duan
  • Deling Li
  • Guixing Qiu
Original Article

DOI: 10.1007/s00296-010-1516-0

Cite this article as:
Hao, D., Li, M., Wu, Z. et al. Rheumatol Int (2011) 31: 1433. doi:10.1007/s00296-010-1516-0

Abstract

The objective of this study was to investigate adiponectin levels in both plasma and synovial fluid of female patients with knee osteoarthritis (OA) and to analyze the correlation between adiponectin and degradation markers of cartilage matrix in synovial fluid. Thirty female patients with knee OA were enrolled in this study. Levels of adiponectin and degradation markers of cartilage matrix were measured using enzyme-linked immunosorbent assay. Adiponectin level in synovial fluid was significantly lower with respect to paired plasma level (0.93 ± 0.64 vs. 7.50 ± 3.29 μg/ml, P < 0.001). Correlation analysis showed that synovial fluid adiponectin significantly correlated with degradation markers of aggrecan, AGG1 (r = 0.441, P = 0.015) and AGG2 (r = 0.445, P = 0.014), but not significantly correlated with degradation marker of collagen II, CTX-II. These findings suggest that adiponectin might involve in the regulation of the degradation of cartilage matrix in OA.

Keywords

Adiponectin Osteoarthritis Synovial fluid Biomarker Aggrecan 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Dongsheng Hao
    • 1
  • Ming Li
    • 1
  • Zhihong Wu
    • 1
  • Yuanhui Duan
    • 1
  • Deling Li
    • 1
  • Guixing Qiu
    • 1
  1. 1.Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina