Rheumatology International

, Volume 31, Issue 2, pp 227–231

A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population

  • Sheng-Quan Zhang
  • Jian-Wen Han
  • Liang-Dan Sun
  • Wen-sheng Lu
  • Xian-Yong Yin
  • Xue-Jun Zhang
  • Sen Yang
Original Article

DOI: 10.1007/s00296-009-1247-2

Cite this article as:
Zhang, SQ., Han, JW., Sun, LD. et al. Rheumatol Int (2011) 31: 227. doi:10.1007/s00296-009-1247-2

Abstract

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Recently, single-nucleotide polymorphisms (SNPs) in tumor necrosis factor (TNF) superfamily gene TNFSF4 have been shown to be associated with SLE in European and Hong Kong Chinese populations. But it is unknown whether it is also associated with the disease in Mainland Chinese Han population. We genotyped the SNPs rs1234315 near the TNFSF4 gene in 1,344 SLE patients and 4,315 controls of Chinese Han population and confirmed the association between the SNP and the SLE [odds ratios (ORs) of 1.45 and P values of 1.5 × 10−16]. The stratification analyses showed that rs1234315 was more strongly associated with SLE patients with arthritis. Our study not only suggested that the TNFSF4 gene was associated with SLE in Chinese Han population, but also implied that it might be a common genetic factor predisposing to the development of SLE in multiple populations.

Keywords

SLE TNFSF4 Chinese Han Genetic association 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Sheng-Quan Zhang
    • 1
    • 2
    • 3
    • 4
  • Jian-Wen Han
    • 1
    • 2
    • 3
  • Liang-Dan Sun
    • 1
    • 2
    • 3
  • Wen-sheng Lu
    • 1
    • 2
    • 3
  • Xian-Yong Yin
    • 1
    • 2
    • 3
  • Xue-Jun Zhang
    • 1
    • 2
    • 3
  • Sen Yang
    • 1
    • 2
    • 3
  1. 1.Department of Dermatology, Institute of DermatologyNo. 1 Hospital, Anhui Medical UniversityHefeiChina
  2. 2.Key Laboratory of DermatologyAnhui Medical University, Ministry of EducationHefeiChina
  3. 3.Department of Dermatology and VenereologyAnhui Medical UniversityHefeiChina
  4. 4.Department of Biochemistry and Molecular BiologyAnhui Medical UniversityHefeiChina

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