Rheumatology International

, Volume 31, Issue 1, pp 65–69

Anti-cyclic citrullinated peptide antibodies as a discriminating marker between rheumatoid arthritis and chronic hepatitis C-related polyarthropathy

  • Wafaa M. Ezzat
  • Hala M. Raslan
  • Azza A. Aly
  • Nahed A. Emara
  • Manal M. El Menyawi
  • Amr Edrees
Original Article

DOI: 10.1007/s00296-009-1225-8

Cite this article as:
Ezzat, W.M., Raslan, H.M., Aly, A.A. et al. Rheumatol Int (2011) 31: 65. doi:10.1007/s00296-009-1225-8

Abstract

Articular involvement is a frequent extrahepatic manifestation of hepatitis C virus (HCV) infection. The distinction between HCV-related polyarthropathy and true RA may be very difficult, especially with recent onset RA before articular damage and erosions develop. The objective of the study is to assess the diagnostic utility of anti-CCP antibodies and compare it with that of rheumatoid factor (RF) in distinguishing between rheumatoid arthritis (RA) and HCV-related polyarthropathy. Anti-cyclic citrullinated peptide (CCP) antibodies and RF were determined in the sera of 30 patients with RA and 22 patients with HCV-related polyarthropathy. Anti-CCP antibodies were positive in 83.3% of patients with RA and in 4.5% in patients with HCV and polyarthropathy. RF was positive in 90% of RA patients and in 81.1% of HCV patients with polyarthropathy. The anti-CCP antibodies showed higher specificity for RA compared with RF (95.4 vs. 18.2%). However, the sensitivity of anti-CCP was comparable to that of RF (83.3 vs. 90%). In conclusions, anti-CCP antibodies are reliable laboratory markers to differentiate between RA and HCV-related polyarthropathy.

Keywords

Rheumatoid arthritis Anti-cyclic citrullinated peptide antibodies Hepatitis C-related polyarthropathy 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Wafaa M. Ezzat
    • 1
  • Hala M. Raslan
    • 1
  • Azza A. Aly
    • 2
  • Nahed A. Emara
    • 2
  • Manal M. El Menyawi
    • 3
  • Amr Edrees
    • 4
  1. 1.Internal Medicine DepartmentNational Research CentreCairoEgypt
  2. 2.Clinical and Chemical Pathology DepartmentNational Research CentreCairoEgypt
  3. 3.Internal Medicine DepartmentKasr El Eini HospitalCairoEgypt
  4. 4.Internal Medicine DepartmentUniversity of MissouriKansas CityUSA

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