Rheumatology International

, 30:415

Mannose binding lectin levels are not related to radiographic damage in ankylosing spondylitis

  • Sibel Zehra Aydin
  • Pamir Atagunduz
  • Burak Erer
  • Cengiz Bahadir
  • Nevsun Inanc
  • Haner Direskeneli
Short Communication

DOI: 10.1007/s00296-009-1189-8

Cite this article as:
Aydin, S.Z., Atagunduz, P., Erer, B. et al. Rheumatol Int (2010) 30: 415. doi:10.1007/s00296-009-1189-8

Abstract

In the current study we aimed to investigate the effect of MBL deficiency in radiographic damage of the spine in a large group of AS patients. One hundred and ninety-one AS patients and 85 healthy controls were studied. Disease activity, radiological scores, and demographic features were recorded. MBL levels were measured with standard ELISA kits. Results showed that median MBL levels in AS and healthy controls were 2,530 (range 0–5,861) ng/ml and 3,415 (0–7,950) ng/ml, respectively (p = 0.1). MBL deficiency (<500 ng/ml) was comparable in both groups (%21.5 in AS, % 17.6; p = 0.5). Disease activity, clinical picture, and therapies were not associated with MBL levels. Both BASRI and mSASSS scores were found similar in AS patients with or without MBL deficiency [BASRI: MBL < 500 ng/ml: 6(2–12), MBL ≥ 500 ng/ml: 6(2–12); p = 0.75], [mSASSS: MBL < 500 ng/ml: 3(0–72), MBL ≥ 500 ng/ml: 5(0–72); p = 0.81]. We conclude that MBL deficiency prevalence is not increased in AS patients and it is not a cause of a severe radiographic damage.

Keywords

Ankylosing spondylitisMannose binding lectinRadiographic damage

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Sibel Zehra Aydin
    • 1
  • Pamir Atagunduz
    • 1
  • Burak Erer
    • 2
  • Cengiz Bahadir
    • 3
  • Nevsun Inanc
    • 1
  • Haner Direskeneli
    • 1
  1. 1.Marmara University Faculty of MedicineIstanbulTurkey
  2. 2.Umraniye Training and Research HospitalIstanbulTurkey
  3. 3.Department of Physical TherapyHaydarpasa Numune HospitalIstanbulTurkey