Rheumatology International

, Volume 30, Issue 5, pp 587–590

The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China

  • Xiang Liu
  • Li-Hua Hu
  • Yi-Rong Li
  • Feng-Hua Chen
  • Yong Ning
  • Qun-Feng Yao
Original Article

DOI: 10.1007/s00296-009-1018-0

Cite this article as:
Liu, X., Hu, L., Li, Y. et al. Rheumatol Int (2010) 30: 587. doi:10.1007/s00296-009-1018-0

Abstract

The aim of this study was to investigate the association of the B27 subtypes with ankylosing spondylitis (AS) in the Wuhan population of China. We selected 317 HLA-B27-positive individuals (145 controls and 172 patients with ankylosing spondylitis). The B27 subtypes were characterized using a PCR-SSP method. Six B27 subtypes were determined: B*2702, 03, 04, 05, 06 and B*13. HLA-B*2704 and HLA-B*2705 were the two high frequency genotypes in controls and patients. Compared with the controls, the AS patients had high frequency of B*2704 (patients 69.2% vs. controls 53.8%) and low frequency of B*2705 (patients 23.8% vs. controls 33.1%). B*2703 was detected in 10 (5.8%) patients and in 13 (8.9%) controls. B*2702, 06 and B*2713 were relatively rare. Our results show that the allele conferring risk to AS in the Wuhan population of China was B*2704 and B*2705. B*2704 is strongly associated with AS.

Keywords

Human leukocyte antigenWuhanHLA-B27SubtypesAnkylosing spondylitis

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Xiang Liu
    • 1
    • 2
  • Li-Hua Hu
    • 1
  • Yi-Rong Li
    • 1
  • Feng-Hua Chen
    • 1
  • Yong Ning
    • 2
  • Qun-Feng Yao
    • 2
  1. 1.Clinical Laboratory Medicine Department, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Medical Laboratory and TechnologyHubei College of Traditional Chinese MedicineWuhanChina