Rheumatology International

, Volume 29, Issue 9, pp 1047–1050

Mycobacterium tuberculosis infection precipitates SLE in patients from endemic areas

  • Kanjaksha Ghosh
  • Manisha Patwardhan
  • Vandana Pradhan
Original Article

DOI: 10.1007/s00296-009-0903-x

Cite this article as:
Ghosh, K., Patwardhan, M. & Pradhan, V. Rheumatol Int (2009) 29: 1047. doi:10.1007/s00296-009-0903-x

Abstract

In a cohort of 70 systemic lupus erythematosus (SLE) patients diagnosed over 2 years period, 14 patients were found to have confirmed antecedent tuberculosis (20.0%) which was 40 times higher (p < 0.001, 95%CI 36.2–48.6) than the prevalence of tuberculosis in the local population. Demonstration of anti-histone antibodies in similar proportion of SLE patients with and without antecedent anti-TB treatment and similar proportion of renal involvement (36 vs. 40%) between anti-TB drug exposed and non-exposed patients ruled out the drugs to be causative factors in precipitating SLE in these patients with antecedent history of tuberculosis. A cohort of 30 confirmed pulmonary tuberculosis patients were also studied in parallel to demonstrate high incidence of autoantibodies in these patients but no SLE. This study suggests a role of prior tuberculosis in precipitating SLE in genetically predisposed patients.

Keywords

SLEM. tuberculosisAutoimmunityEndemic areaDrug induced SLE

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Kanjaksha Ghosh
    • 1
  • Manisha Patwardhan
    • 1
  • Vandana Pradhan
    • 1
  1. 1.Department of Immunology and AutoimmunedisordersNational Institute of Immunohaematology (ICMR)MumbaiIndia