Abstract
Schönlein-Henoch purpura is a small vessel disease that affects mainly skin and kidney, although several gastrointestinal symptoms may occur including abdominal pain, intussusception, perforation or bleeding. Massive lower gastrointestinal haemorrhage is rare and even more as the main symptom of the disease. We present a case of a 2-year-old boy with Schönlein-Henoch purpura who developed a massive lower gastrointestinal bleeding requiring blood transfusion. In this patient both Schönlein-Henoch purpura and gastrointestinal haemorrhage were successfully treated with intravenous methylprednisolone, avoiding surgical intervention. Physicians need to have a high index of suspicion when evaluating these patients, even more when dermatologic signs are scarce. Glucocorticosteroid therapy may be effective when treating severe gastrointestinal symptoms.
References
Gardner-Medwin JM, Dolezalova P, Cummins C, Southwood TR (2002) Incidence of Henoch–Schonlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet 360:1197–1202. doi:10.1016/S0140-6736(02)11279-7
Blanco R, Martinez-Taboada VM, Rodriguez-Valverde V, García Fuentes M, Gonzalez-Gay MA (1997) Henoch–Schonlein purpura in adulthood and childhood: two different expressions of the same syndrome. Arthritis Rheum 40:859–864. doi:10.1002/art.1780400513
Yang YH, Hung CF, Hsu CR, Wang LC, Chuang YH, Lin YT, Chiang BL (2005) A nationwide survey on epidemiological characteristics of childhood Henoch–Schonlein purpura in Taiwan. Rheumatology (Oxford) 44:618–622. doi:10.1093/rheumatology/keh544
Trapani S, Micheli A, Grisolia F, Resti M, Chiappini E, Falcini F, De Martino M (2005) Henoch–Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature. Semin Arthritis Rheum 35:143–153. doi:10.1016/j.semarthrit.2005.08.007
Mills JA, Michel BA, Bloch DA, Calabrese LH, Hunder GG, Arend WP et al (1990) The American College of Rheumatology 1990 criteria for the classification of Henoch–Schonlein purpura. Arthritis Rheum 33:1114–1121. doi:10.1002/art.1780330521
Ozen S, Ruperto N, Dillon MJ, Bagga A, Barron K, Davin JC et al (2006) EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides. Ann Rheum Dis 65:936–941. doi:10.1136/ard.2005.046300
Calviño MC, Llorca J, García-Porrúa C, Fernández-Iglesias JL, Rodriguez-Ledo P, González-Gay MA (2001) Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study. Medicine (Baltimore) 80(5):279–290. doi:10.1097/00005792-200109000-00001
Saulsbury FT (1999) Henoch-Schönlein purpura in children. Report of 100 patients and review of the literature. Medicine (Baltimore) 78(6):395–409. doi:10.1097/00005792-199911000-00005
Chang WL, Yang YH, Lin YT, Chiang BL (2004) Gastrointestinal manifestations in Henoch-Schönlein purpura: a review of 261 patients. Acta Paediatr 93(11):1427–1431. doi:10.1080/08035250410020181
Zhang Y, Huang X (2008) Gastrointestinal involvement in Henoch-Schönlein purpura. Scand J Gastroenterol 43(9):1038–1043. doi:10.1080/00365520802101861
Jennette JC, Falk RJ (1997) Small-vessel vasculitis. N Engl J Med 337:1512–1523. doi:10.1056/NEJM199711203372106
Caksen H, Odabas D, Kosem M, Arslan S, Oner AF, Atas B et al (2002) Report of eight infants with acute infantile hemorrhagic edema and review of the literature. J Dermatol 29:290–295
Calabrese LH, Michel BA, Bloch DA, Michel BA, Hunder GG, Arend WP et al (1990) The American College of Rheumatology 1990 criteria for the classification of hypersensitivity vasculitis. Arthritis Rheum 33:1108–1113
Ronkainen J, Koskimies O, Ala-Houhala M, Antikainen M, Merenmies J, Rajantie J, Ormala T, Turtinen J, Nuutinen M (2006) Early prednisone therapy in Henoch–Scönlein purpura: a randomized, double blind, placebo controlled trial. J Pediatr 149(2):241–247. doi:10.1016/j.jpeds.2006.03.024
Lawee D (2008) Atypical clinical course of Henoch–Schonlein purpura. Can Fam Physician 54(8):1117–1120
Weiss PF, Feinstein JA, Luan X, Burnham JM, Feudtner C (2007) Effects of corticosteroid on Henoch-Schönlein purpura: a systematic review. Pediatrics 120(5):1079–1087. doi:10.1542/peds.2007-0667
Wang L, Huang FC, Ko SF, Cheng MT (2003) Successful treatment of mesenteric vasculitis caused by Henoch-Schönlein purpura with methylprednisolone pulse therapy. Clin Rheumatol 22(2):140–142. doi:10.1007/s10067-002-0676-z
Shin JI, Park JM, Shin YH, Kim JH, Kim PK, Lee JS, Jeong HJ (2005) Cyclosporine A therapy for severe Henoch-Schönlein nephritis with nephritic syndrome. Pediatr Nephrol 20(8):1093–1097. doi:10.1007/s00467-005-1864-2
Tarshish P, Bernstein J, Edelmann CM Jr (2004) Henoch-Schönlein purpura nephritis: course of disease and efficacy of cyclophosphamide. Pediatr Nephrol 19(1):51–56. doi:10.1007/s00467-003-1315-x
Rech J, Fuchs F, Kallert S, Hueber AJ, Requadt C, Manger B, Kalden JR, Amann K, Strauss R, Schulze-Koops H (2007) Plasmapheresis therapy in an elderly patient with rapidly progressive Henoch-Schönlein purpura with disseminated organ involvement. Clin Rheumatol 26(1):112–114. doi:10.1007/s10067-005-0113-1
Lamireau T, Rebouissoux L, Hehunstre J-P (2001) Intravenous immunoglobulin therapy for severe digestive manifestations of Henoch-Schönlein purpura. Acta Paediatr 90:1081–1082
Ebert EC (2008) Gastrointestinal manifestations of Henoch–Schonlein Purpura. Dig Dis Sci 53(8):2011–2019. doi:10.1007/s10620-007-0147-0
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Álvarez-Caro, F., Concha-Torre, J.A., García-Hernández, I. et al. Massive lower gastrointestinal haemorrhage, successfully treated with corticosteroids, as main symptom of Schönlein-Henoch purpura. Rheumatol Int 29, 1491–1494 (2009). https://doi.org/10.1007/s00296-009-0853-3
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DOI: https://doi.org/10.1007/s00296-009-0853-3