Rheumatology International

, 29:173

Interleukin-17F gene polymorphisms in Korean patients with Behçet’s disease

Authors

  • Won-Cheoul Jang
    • Department of ChemistrySchool of Advanced Science, Dankook University
  • Yun-Hyoung Nam
    • Department of ChemistrySchool of Advanced Science, Dankook University
  • Young-Chang Ahn
    • Department of ChemistrySchool of Advanced Science, Dankook University
  • Sang-Hyun Lee
    • Department of ChemistrySchool of Advanced Science, Dankook University
  • Sung-Hoon Park
    • Department of Internal MedicineCatholic University of Daegu School of Medicine
  • Jung-Yoon Choe
    • Department of Internal MedicineCatholic University of Daegu School of Medicine
  • Shin-Seok Lee
    • Department of Internal MedicineChonnam National University Medical School
    • Department of Internal MedicineCatholic University of Daegu School of Medicine
Original Article

DOI: 10.1007/s00296-008-0664-y

Cite this article as:
Jang, W., Nam, Y., Ahn, Y. et al. Rheumatol Int (2008) 29: 173. doi:10.1007/s00296-008-0664-y

Abstract

IL-17 is a novel cytokine that is characterized by an ability to induce several types of cells to secrete proinflammatory cytokines in various inflammatory diseases. This study analyzed the influence of IL-17F gene polymorphisms on disease susceptibility and clinical features. Ninety-nine Behçet’s disease (BD) patients and 114 controls were genotyped to analyze three single nucleotide polymorphisms (SNPs) including A126G, G155A, and A161G of the IL-17F gene using automated sequencing. We compared the frequencies of IL-17F alleles, genotypes, and haplotypes in patients with BD and controls using the chi-square or Fisher’s exact test. Significant differences in the frequencies of allele and genotype in A126G SNP of IL-17 gene were found between BD patients and controls (P < 0.001 and P < 0.001, respectively). None of three IL-17F SNPs were associated with diverse clinical features in BD. The frequency of haplotype AA did not differ between patients with BD and controls (P = 0.985). The haplotypes, AG, and GG, have positive and inverse association with BD susceptibility (P < 0.001 and P < 0.001, respectively). These findings suggest that IL-17 gene SNPs may influence the susceptibility of BD.

Keywords

IL-17FPolymorphismsBehçet’s disease

Copyright information

© Springer-Verlag 2008