Rheumatology International

, 29:173

Interleukin-17F gene polymorphisms in Korean patients with Behçet’s disease

  • Won-Cheoul Jang
  • Yun-Hyoung Nam
  • Young-Chang Ahn
  • Sang-Hyun Lee
  • Sung-Hoon Park
  • Jung-Yoon Choe
  • Shin-Seok Lee
  • Seong-Kyu Kim
Original Article

DOI: 10.1007/s00296-008-0664-y

Cite this article as:
Jang, WC., Nam, YH., Ahn, YC. et al. Rheumatol Int (2008) 29: 173. doi:10.1007/s00296-008-0664-y
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Abstract

IL-17 is a novel cytokine that is characterized by an ability to induce several types of cells to secrete proinflammatory cytokines in various inflammatory diseases. This study analyzed the influence of IL-17F gene polymorphisms on disease susceptibility and clinical features. Ninety-nine Behçet’s disease (BD) patients and 114 controls were genotyped to analyze three single nucleotide polymorphisms (SNPs) including A126G, G155A, and A161G of the IL-17F gene using automated sequencing. We compared the frequencies of IL-17F alleles, genotypes, and haplotypes in patients with BD and controls using the chi-square or Fisher’s exact test. Significant differences in the frequencies of allele and genotype in A126G SNP of IL-17 gene were found between BD patients and controls (P < 0.001 and P < 0.001, respectively). None of three IL-17F SNPs were associated with diverse clinical features in BD. The frequency of haplotype AA did not differ between patients with BD and controls (P = 0.985). The haplotypes, AG, and GG, have positive and inverse association with BD susceptibility (P < 0.001 and P < 0.001, respectively). These findings suggest that IL-17 gene SNPs may influence the susceptibility of BD.

Keywords

IL-17FPolymorphismsBehçet’s disease

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Won-Cheoul Jang
    • 1
  • Yun-Hyoung Nam
    • 1
  • Young-Chang Ahn
    • 1
  • Sang-Hyun Lee
    • 1
  • Sung-Hoon Park
    • 2
  • Jung-Yoon Choe
    • 2
  • Shin-Seok Lee
    • 3
  • Seong-Kyu Kim
    • 2
  1. 1.Department of ChemistrySchool of Advanced Science, Dankook UniversityCheonanSouth Korea
  2. 2.Department of Internal MedicineCatholic University of Daegu School of MedicineDaeguSouth Korea
  3. 3.Department of Internal MedicineChonnam National University Medical SchoolGwangjuSouth Korea