Case Report

Rheumatology International

, Volume 28, Issue 10, pp 1049-1051

First online:

Polyarteritis nodosa presenting as pancytopenia: case report and review of the literature

  • Leslie R. HarroldAffiliated withDepartment of Medicine, University of Massachusetts Medical School Email author 
  • , Nancy Y. N. LiuAffiliated withDepartment of Medicine, University of Massachusetts Medical School

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Polyarteritis nodosa (PAN) is not commonly associated with hematologic abnormalities. We report the first case of pancytopenia as the presenting symptom of PAN. There was no associated malignancy or reactive hemophagocytic syndrome (RHS) to explain the findings. The patient, after successful treatment of PAN, subsequently developed RHS a few years later. He is the fourth reported case of RHS in a patient with PAN. In addition to describing the patient’s presentation and clinical course, a systematic review of the literature was performed examining the association between hematologic conditions, including RHS, and PAN.


Pancytopenia, Polyarteritis nodosa, Hemophagocytic syndrome