Original Article

Rheumatology International

, Volume 28, Issue 7, pp 685-691

First online:

Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility

  • Berna TanderAffiliated withDepartment of Physical Medicine and Rehabilitation, Ondokuzmayis University School of Medicine Email author 
  • , Sezgin GunesAffiliated withDepartment of Medical Biology and Genetics, School of Medicine, Ondokuzmayis University
  • , Omer BokeAffiliated withDepartment of Psychiatry, School of Medicine, Ondokuzmayis University
  • , Gamze AlayliAffiliated withDepartment of Physical Medicine and Rehabilitation, Ondokuzmayis University School of Medicine
  • , Nurten KaraAffiliated withDepartment of Medical Biology and Genetics, School of Medicine, Ondokuzmayis University
  • , Hasan BagciAffiliated withDepartment of Medical Biology and Genetics, School of Medicine, Ondokuzmayis University
  • , Ferhan CanturkAffiliated withDepartment of Physical Medicine and Rehabilitation, Ondokuzmayis University School of Medicine

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Abstract

Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P > 0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS.

Keywords

Fibromyalgia Gene polymorphism 102T/C 5-HT2A −1438G/A