, Volume 27, Issue 1, pp 115-116
Date: 09 Sep 2006

Premature myocardial infarction in a young woman with systemic lupus erythematosus

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Sirs,

Cardiovascular disease is a major cause of mortality in systemic lupus erythematosus (SLE). It may consist of pericarditis, myocarditis, endocarditis, and may affect coronary arteries. Most often, cardiac involvement is subclinical. Clinically significant cardiac lesions are limited [1, 2] Coronary artery disease may develop due to vasculitis, premature atherosclerosis or antiphospholipid antibodies in SLE. Premature atherosclerosis is the most frequent cause of coronary artery disease in the patients. The early onset and severity of atherosclerosis in various rheumatic diseases were described with experimental and clinical studies [3]. A significant correlation was found between SLE and premature or accelerated coronary atherosclerosis [4]. However, the mechanisms of premature atherosclerosis associated with SLE are still unknown.

Here, we present a young female patient with SLE, who developed myocardial infarction, the leading cause of her death.

Case report

A 30-year-old female wh ...