, Volume 27, Issue 3, pp 263-267
Date: 25 Aug 2006

Arthritis as a presenting symptom in a hypogammaglobulinemic patient with thymectomy

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Common variable immunodeficiency (CVID) and Good’s syndrome are both associated with immunodeficiency characterized by hypogammaglobulinemia and autoimmune manifestations. Patients with hypogammaglobulinemia may present with bone and joint abnormalities such as arthritis, being the most prevalent and sometimes resembling rheumatoid arthritis.

Case report

A 46-year-old man referred to the Rheumatology Department with the diagnosis of rheumatoid arthritis. He has been suffering from pain and swelling of distal and proximal interphalangeal joints improving with nonsteroidal anti-inflammatory drugs since 1996.

In the medical history, the patient reported an operation due to mediastinal mass detected by a plain chest film in 1994 when he was admitted to the hospital with a 4-month history of weight loss, malaise and weekness in his legs. The histological evaluation had revealed thymoma and he did not report any medical treatment after operation. He has been suffering from cough, pu ...