Classic disease modifying anti-rheumatic drugs (DMARDs) in combination with infliximab. The Finnish experience

  • D.C. Nordström
  • L. Konttinen
  • M. Korpela
  • T. Tiippana-Kinnunen
  • K. Eklund
  • S. Forsberg
  • K. Ilva
  • O. Kaipiainen-Seppänen
  • T. Malmi
  • T. Ylä-Kerttula
  • V. Honkanen
Original Article

DOI: 10.1007/s00296-005-0054-7

Cite this article as:
Nordström, D., Konttinen, L., Korpela, M. et al. Rheumatol Int (2006) 26: 741. doi:10.1007/s00296-005-0054-7

Abstract

To assess the performance of infliximab in a clinical setting, 364 rheumatoid arthritis (RA) patients from the National Register of Biological Treatment in Finland (ROB-FIN) were analysed. Corticosteroid usage and dose diminished (p<0.05 and 0.001, respectively) in patients on infliximab, of whom 51% also used one, 28% two and 16% three other concomitant DMARDs. A 34% of the RA patients used methotrexate ± corticosteroids without any other DMARD. Methotrexate was most frequently used with sulphasalazine and/or hydroxychloroquine. Non-methotrexate patients most frequently used leflunomide or azathioprine combined with corticosteroids. The clinical effect of these combinations was similar to that of infliximab with methotrexate alone. The results indicate that infliximab can be used together with other DMARDs than methotrexate alone, quite according to the philosophy of the combination drug therapy, as the effectiveness is as good as or even slightly better than that of methotrexate and infliximab.

Keywords

BiologicalsEffectivenessCombination therapy

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • D.C. Nordström
    • 1
  • L. Konttinen
    • 2
    • 3
  • M. Korpela
    • 4
  • T. Tiippana-Kinnunen
    • 5
  • K. Eklund
    • 5
  • S. Forsberg
    • 6
  • K. Ilva
    • 7
  • O. Kaipiainen-Seppänen
    • 8
  • T. Malmi
    • 9
  • T. Ylä-Kerttula
    • 10
  • V. Honkanen
    • 11
  1. 1.Department of Internal MedicineHelsinki University Central HospitalHelsinkiFinland
  2. 2.ORTON Orthopaedic Hospital of the Invalid FoundationHelsinkiFinland
  3. 3.COXA Joint Replacement HospitalTampereFinland
  4. 4.Division of RheumatologyTampere University HospitalTampereFinland
  5. 5.Division of RheumatologyHelsinki University Central HospitalHelsinkiFinland
  6. 6.Joensuu Central HospitalJoensuuFinland
  7. 7.Hämeenlinna Central HospitalHämeenlinnaFinland
  8. 8.Department of MedicineKuopio University Hospital KuopioFinland
  9. 9.Department of Internal MedicineSeinäjoki Central HospitalSeinäjokiFinland
  10. 10.Division of RheumatologyTurku University Central HospitalTurkuFinland
  11. 11.Rheumatism Foundation HospitalHeinolaFinland