Case Report

Rheumatology International

, Volume 25, Issue 4, pp 311-313

First online:

Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy

  • Byung-Ryul ChoiAffiliated withHospital for Rheumatic Diseases, Hanyang University
  • , Myung-Ju AhnAffiliated withDepartment of Internal Medicine, Hanyang University College of Medicine
  • , Woong Soo LeeAffiliated withDepartment of Laboratory Medicine, Hanyang University College of Medicine
  • , Tae-Hwan KimAffiliated withHospital for Rheumatic Diseases, Hanyang University
  • , Sang-Cheol BaeAffiliated withHospital for Rheumatic Diseases, Hanyang University
  • , Jae-Bum JunAffiliated withHospital for Rheumatic Diseases, Hanyang University Email author 

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Abstract

Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (total dose 1702.5 mg). This may be the first such case reported in the literature.

Keywords

Acute erythroleukemia Low-dose methotrexate Rheumatoid arthritis