Rheumatology International

, Volume 22, Issue 4, pp 138–141

Serum leptin levels in women with systemic lupus erythematosus

Authors

  • Araceli Garcia-Gonzalez
    • Divisions of Musculoskeletal, Autoimmune, and Metabolic Diseases, Clinical Epidemiology Research Unit, Hospital de Especialidades del Centro Medico Nacional de Occidente, Belisario Domínguez 1000, Guadalajara, Jalisco, Mexico 44320
  • Laura Gonzalez-Lopez
    • Department of Internal Medicine-Rheumatology, Hospital General Regional 110, Prolongación Circunvalación Oblatos, Guadalajara, Jalisco, Mexico
  • Isela C. Valera-Gonzalez
    • Divisions of Musculoskeletal, Autoimmune, and Metabolic Diseases, Clinical Epidemiology Research Unit, Hospital de Especialidades del Centro Medico Nacional de Occidente, Belisario Domínguez 1000, Guadalajara, Jalisco, Mexico 44320
  • Ernesto G. Cardona-Muñoz
    • Department of Internal Medicine-Cardiology, Hospital General Regional 45, San Felipe 1014, Guadalajara, Jalisco, Mexico
  • Mario Salazar-Paramo
    • Divisions of Musculoskeletal, Autoimmune, and Metabolic Diseases, Clinical Epidemiology Research Unit, Hospital de Especialidades del Centro Medico Nacional de Occidente, Belisario Domínguez 1000, Guadalajara, Jalisco, Mexico 44320
  • Manuel González-Ortiz
    • Divisions of Musculoskeletal, Autoimmune, and Metabolic Diseases, Clinical Epidemiology Research Unit, Hospital de Especialidades del Centro Medico Nacional de Occidente, Belisario Domínguez 1000, Guadalajara, Jalisco, Mexico 44320
  • Esperanza Martínez-Abundis
    • Divisions of Musculoskeletal, Autoimmune, and Metabolic Diseases, Clinical Epidemiology Research Unit, Hospital de Especialidades del Centro Medico Nacional de Occidente, Belisario Domínguez 1000, Guadalajara, Jalisco, Mexico 44320
  • Jorge I. Gamez-Nava
    • Divisions of Musculoskeletal, Autoimmune, and Metabolic Diseases, Clinical Epidemiology Research Unit, Hospital de Especialidades del Centro Medico Nacional de Occidente, Belisario Domínguez 1000, Guadalajara, Jalisco, Mexico 44320
Original Article

DOI: 10.1007/s00296-002-0216-9

Cite this article as:
Garcia-Gonzalez, A., Gonzalez-Lopez, L., Valera-Gonzalez, I.C. et al. Rheumatol Int (2002) 22: 138. doi:10.1007/s00296-002-0216-9

Abstract

The purpose of this study was to evaluate serum leptin levels in systemic lupus erythematosus (SLE). Forty-one women with SLE were compared with 23 healthy women of similar age and body mass index (BMI). Clinical characteristics and Mexican systemic lupus erythematosus disease activity index (Mex-SLEDAI) score were assessed. Serum leptin levels (ng/dl) were measured by enzyme-linked immunosorbent assay (ELISA). Comparisons of leptin levels were made with the Mann-Whitney U-test. In a multiple regression analysis, those factors that could influence the leptin levels were adjusted. Patients with SLE had higher leptin levels than the control group (SLE median 31 vs control median 15, P=0.023). After adjusting by other variables, the serum leptin levels remained higher in SLE than in controls (P=0.02). Patients with SLE had no association between leptin levels and Mex-SLEDAI score, age, duration of disease, or prednisone doses. Those with SLE had higher leptin levels than controls. Further longitudinal studies are required to evaluate the role of this hormone in the exacerbations of SLE.

Leptin Hormones Systemic lupus erythematosus

Copyright information

© Springer-Verlag 2002