Rheumatology International

, Volume 21, Issue 3, pp 97–102

Bone mineral density, biochemical markers of bone turnover, and hormonal status in men with systemic lupus erythematosus

  • Harjit Bhattoa
  • Emese Kiss
  • Peter Bettembuk
  • Adam Balogh
Original Article

DOI: 10.1007/s00296-001-0149-8

Cite this article as:
Bhattoa, H., Kiss, E., Bettembuk, P. et al. Rheumatol Int (2001) 21: 97. doi:10.1007/s00296-001-0149-8

Abstract.

The aim of this study was to evaluate bone mineral density (BMD), biochemical markers of bone turnover, and hormone levels in men with systemic lupus erythematosus (SLE). BMD at L2–L4 lumbar vertebrae (LS), left proximal femur neck, and radius at the ultradistal and mid-33% region was measured by dual-energy X-ray absorptiometry in 23 men with SLE (mean age, disease duration, and cumulative corticosteroid dose were 45.6 years, 11.9 years, and 33.410 g, respectively) and 40 healthy, age- and sex-matched controls. Biochemical markers of bone turnover, parathyroid hormone and 25-hydroxyvitamin D (25-OH-D), testosterone, and dehydroepiandrosterone sulfate (DHEAS) levels were measured. There was no difference in BMD between the SLE and control group. The prevalence of osteoporosis was 17.4% (4 out of 23), found at LS. Biochemical markers of bone turnover were within the reference range. There was a high prevalence of hypovitaminosis D (65.2%), hypotestosteronism (62.5%), and hypodehydroepiandrosterone sulfate (100%). There was no correlation between BMD and duration of disease, corticosteroid doses, SLE Disease Activity Index (SLEDAI), SLE Collaboration Clinics/American College of Rheumatology (SLICC/ARC) damage index, or markers of bone turnover. Bone-specific alkaline phosphatase (BSAP) (r, –0.500; P=0.018) and DHEAS (r, –0.511; P=0.013) correlated with the daily corticosteroid dose. Despite corticosteroid therapy, bone mass in men with SLE was not decreased.

Systemic lupus erythematosus Men Bone mineral density Biochemical markers of bone turnover Hormones Corticosteroids

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Harjit Bhattoa
    • 1
  • Emese Kiss
    • 2
  • Peter Bettembuk
    • 1
  • Adam Balogh
    • 1
  1. 1.Regional Osteoporosis Center, Department of Obstetrics and Gynecology, Medical and Health Sciences Center, University of Debrecen, Nagyerdei Krt. 98, 4012 Debrecen, Hungary
  2. 2.3rd Department of Internal Medicine, Medical and Health Sciences Center, University of Debrecen, Moricz Zsigmond u. 22, 4004 Debrecen, Hungary