ORIGINAL PAPER

Current Genetics

, Volume 33, Issue 1, pp 16-20

Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor

  • Oren SchuldinerAffiliated withDepartment of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat-Ram, Jerusalem 91904, Israel Fax: 972-2-6586975 e-mail: nissimb@leonardo.ls.huji.ac.il
  • , Chen YanoverAffiliated withDepartment of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat-Ram, Jerusalem 91904, Israel Fax: 972-2-6586975 e-mail: nissimb@leonardo.ls.huji.ac.il
  • , N. BenvenistyAffiliated withDepartment of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat-Ram, Jerusalem 91904, Israel Fax: 972-2-6586975 e-mail: nissimb@leonardo.ls.huji.ac.il

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Abstract

The completion of the yeast genome project enables an analysis of various phenomena for a whole eukaryotic genome. We aimed at characterizing a full spectrum of target genes for a transcription activator, and specifically characterized putative targets for GCN4 in the budding yeast. The results suggest that about 1% of the genes are regulated by GCN4 and that these genes code for proteins involved in amino-acid and nucleotide metabolism. Our analysis proposes that, when enough data about the binding nature of a transcription factor exists, it is possible to identify its putative targets and also to try and assign a physiological role for this transcription factor.

Key words GCN4 Genome S. cerevisiae Transcription factor