Abstract
The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.
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Acknowledgements
This work was supported by grants from the Swedish Research Council (to MF, N-GL and CMG), the Swedish Cancer Society (to CMG), the Swedish Foundation for Strategic Research (to N-GL and CMG), the Swedish National Board for Laboratory Animals (to MF and CMG) and the Emil and Wera Cornell’s foundation (to MF).
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Linder, T., Park, C.B., Asin-Cayuela, J. et al. A family of putative transcription termination factors shared amongst metazoans and plants. Curr Genet 48, 265–269 (2005). https://doi.org/10.1007/s00294-005-0022-5
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DOI: https://doi.org/10.1007/s00294-005-0022-5