Current Genetics

, Volume 47, Issue 1, pp 18–28

The yeast VPS genes affect telomere length regulation

  • Ofer Rog
  • Sarit Smolikov
  • Anat Krauskopf
  • Martin Kupiec
Research Article

DOI: 10.1007/s00294-004-0548-y

Cite this article as:
Rog, O., Smolikov, S., Krauskopf, A. et al. Curr Genet (2005) 47: 18. doi:10.1007/s00294-004-0548-y

Abstract

Eukaryotic cells invest a large proportion of their genome in maintaining telomere length homeostasis. Among the 173 non-essential yeast genes found to affect telomere length, a large proportion is involved in vacuolar traffic. When mutated, these vacuolar protein-sorting (VPS) genes lead to telomeres shorter than those observed in the wild type. Using genetic analysis, we characterized the pathway by which VPS15, VPS34, VPS22, VPS23 and VPS28 affect the telomeres. Our results indicate that these VPS genes affect telomere length through a single pathway and that this effect requires the activity of telomerase and the Ku heterodimer, but not the activity of Tel1p or Rif2p. We present models to explain the link between vacuolar traffic and telomere length homeostasis.

Keywords

TelomeresKu heterodimerVPS geneVacuoleSch9ESCRT

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Ofer Rog
    • 1
  • Sarit Smolikov
    • 1
  • Anat Krauskopf
    • 1
  • Martin Kupiec
    • 1
  1. 1.Department of Molecular Microbiology and BiotechnologyTel Aviv UniversityRamat AvivIsrael