Current Genetics

, Volume 44, Issue 6, pp 287–294

RNA polymerase II transcription apparatus in Schizosaccharomyces pombe

Review Article

DOI: 10.1007/s00294-003-0446-8

Cite this article as:
Mitsuzawa, H. & Ishihama, A. Curr Genet (2004) 44: 287. doi:10.1007/s00294-003-0446-8

Abstract

Eukaryotic RNA polymerase II (Pol II) transcription apparatus is a multi-protein complex consisting of the RNA polymerase II core enzyme (12 subunits), general transcription factors, the mediator, and some other specific accessory factors with regulatory functions. After genome sequencing was completed, the fission yeast Schizosaccharomyces pombe was recognized as a good model organism to study the Pol II transcription apparatus, because most genetic methods developed with the budding yeast Saccharomyces cerevisiae are applicable but the genetic systems of Sch. pombe, including transcription, are closer to those in higher eukaryotes. Recent studies on components of the Sch. pombe basal transcription machinery not only revealed a number of properties common in other eukaryotes but also illuminated some features unique to Sch. pombe. Convergence of information from both yeasts will provide us with a more general understanding of eukaryotic transcription.

Keywords

Schizosaccharomyces pombeRNA polymerase IITFIIDTAFSAGA

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Division of Molecular BiologyNippon Institute for Biological ScienceTokyoJapan
  2. 2.Department of Molecular GeneticsNational Institute of GeneticsShizuokaJapan