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Das duktale Pankreaskarzinom und seine Vorläufer

Pancreatic ductal adenocarcinoma and its precursors

  • Schwerpunkt: Pankreaspathologie
  • Published:
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Zusammenfassung

Das duktale Adenokarzinom des Pankreas ist der bei weitem häufigste maligne Pankreastumor. Es gehört zu den Tumoren mit schlechter Prognose. Die morphologischen Charakteristika sind: bevorzugte Lokalisation im Pankreaskopf, duktal-glanduläre Tumorstrukturen verbunden mit ausgeprägter Desmoplasie und CEA- und MUC1-Positivität. Varianten dieses Karzinoms sind das adenosquamöse Karzinom, das undifferenzierte pleomorphe Karzinom sowie der gemischte duktal-endokrine Tumor. Mit der Definition von Gangveränderungen als pankreatische intraepitheliale Neoplasie (PanIN) konnten ein Progressionsmodell für die Entstehung des duktalen Pankreaskarzinoms entwickelt und korrespondierende Genalterationen nachgewiesen werden.

Abstract

Pancreatic ductal adenocarcinoma is the most frequent malignant pancreatic tumor. It is one of the tumors that has a particularly poor prognosis. Its morphological characteristics are: preferential localization in the head of the pancreas, ductal-glandular tumor structures combined with marked desmoplasia and CEA and MUC1 positivity. Variants of this carcinoma include adenosquamous carcinomas, undifferentiated pleomorphic carcinomas and mixed ductal-endocrine tumors. With the definition of ductal lesions as pancreatic intraepithelial neoplasia, a progression model for pancreatic ductal carcinoma has been developed and corresponding gene alterations have been detected.

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Authors and Affiliations

  1. Institut für Allgemeine Pathologie, Universität Kiel

    J. Lüttges & G. Klöppel

  2. Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig-Holstein — Campus Kiel, Michaelisstraße 11, 24105, Kiel

    J. Lüttges

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Correspondence to J. Lüttges.

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Lüttges, J., Klöppel, G. Das duktale Pankreaskarzinom und seine Vorläufer. Pathologe 26, 12–17 (2005). https://doi.org/10.1007/s00292-004-0735-0

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  • DOI: https://doi.org/10.1007/s00292-004-0735-0

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