, Volume 44, Issue 3, pp 345-351

Stirring speed influence study on the microencapsulation process and on the drug release from microcapsules

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Microparticles in the size range of 20–200 μm, loaded with drug model were prepared by complex coacervation method. The influence of the agitation rate of dispersion on the morphology of particles and on the drug release has been studied. Obtained results show that the relationship found between the Sauter mean diameter of particles and the stirring speed of emulsification is in good agreement with the inertial breakup theory. The paper reports the preliminary results of a work intended to link up the process control parameters of the microencapsulation and the factors controlling the drug release.

Received: 5 January 2000/Accepted: 3 March 2000