Article

Polymer Bulletin

, Volume 38, Issue 4, pp 387-393

Synthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activity

  • Chun Ho KimAffiliated withDepartment of Industrial Chemistry, College of Engineering, Hanyang University
  • , Jang Won ChoiAffiliated withDepartment of Industrial Chemistry, College of Engineering, Hanyang University
  • , Heung Jae ChunAffiliated withDepartment of Industrial Chemistry, College of Engineering, Hanyang University
  • , Kyu Suk ChoiAffiliated withDepartment of Industrial Chemistry, College of Engineering, Hanyang University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

N-alkyl chitosan derivatives were prepared by introducing alkyl groups into the amine groups of chitosan via Schiff’s base intermediates. Quaternization of the N-alkyl chitosan derivatives were carried out using methyl iodide to produce water soluble cationic polyelectrolytes, novel chitosan derivatives with quaternary ammonium salt. Their antibacterial activities against S. aureus were explored by the viable cell counting method in acetate buffer(pH 6.0). The antibacterial activities of the chitosan derivatives with quaternary ammonium salt increased with increase in the chain length of the alkyl substituent, and this increased activity could be ascribed to the contribution of the increased hydrophobic properties of the derivatives.